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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Longitudinal changes in CD4
+
T-cell memory responses induced by BCG vaccination of newborns
Journal of Infectious Diseases, Volume 207, No. 7, Year 2013
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Description
Background. Improved vaccination strategies against tuberculosis are needed, such as approaches to boost immunity induced by the current vaccine, BCG. Design of these strategies has been hampered by a lack of knowledge of the kinetics of the human host response induced by neonatal BCG vaccination. Furthermore, the functional and phenotypic attributes of BCG-induced long-lived memory T-cell responses remain unclear.Methods. We assessed the longitudinal CD4+ T-cell response following BCG vaccination of human newborns. The kinetics, function, and phenotype of these cells were measured using flow cytometric whole-blood assays.Results. We showed that the BCG-specific CD4 + T-cell response peaked 6-10 weeks after vaccination and gradually waned over the first year of life. Highly activated T-helper 1 cells, predominantly expressing interferon, tumor necrosis factor α, and/or interleukin 2, were present at the peak response. Following contraction, BCG-specific CD4+ T cells expressed high levels of Bcl-2 and displayed a predominant CD45RA-CCR7+ central memory phenotype. However, cytokine and cytotoxic marker expression by these cells was more characteristic of effector memory cells.Conclusions. Our findings suggest that boosting of BCG-primed CD4+ T cells with heterologous tuberculosis vaccines may be best after 14 weeks of age, once an established memory response has developed. © 2013 The Author.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3583271/bin/supp_207_7_1084__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3583271/bin/supp_jis941_jis941supp.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3583271/bin/supp_jis941_jis941supp_fig1.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3583271/bin/supp_jis941_jis941supp_fig2.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3583271/bin/supp_jis941_jis941supp_fig3.tif
Authors & Co-Authors
Soares, Andreia P.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Kwong Chung, Cheong K.C.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Choice, Terry
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Hughes, Elizabeth Jane
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Jacobs, Gail
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Van Rensburg, Esme Janse
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Khomba, Gloria
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
de Kock, Marwou
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Lerumo, Lesedi
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Makhethe, Lebohang
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Maneli, Mbulelo H.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Pienaar, Bernadette
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Smit, Erica
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Tena-Coki, Nontobeko G.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Van Wyk, Leandre
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Boom, W. Henry
United States, Cleveland
University Hospitals Case Medical Center
Kaplan, Gilla
United States, Newark
Public Health Research Institute
Scriba, Thomas J.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Hanekom, Willem Albert
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Statistics
Citations: 111
Authors: 19
Affiliations: 3
Identifiers
Doi:
10.1093/infdis/jis941
ISSN:
00221899
Research Areas
Cancer
Maternal And Child Health
Study Design
Cohort Study