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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A diagnostic autoantibody signature for primary cutaneous melanoma
Oncotarget, Volume 9, No. 55, Year 2018
Notification
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Description
Melanoma is an aggressive form of skin cancer that is curable by surgical excision in the majority of cases, if detected at an early stage. To improve early stage melanoma detection, the development of a highly sensitive diagnostic test is of utmost importance. Here we aimed to identify antibodies to a panel of tumour associated antigens that can differentiate primary melanoma patients and healthy individuals. A total of 245 sera from primary melanoma patients and healthy volunteers were screened against a high-throughput microarray platform containing 1627 functional proteins. Following rigorous statistical analysis, we identified a combination of 10 autoantibody biomarkers that, as a panel, displays a sensitivity of 79%, specificity of 84% and an AUC of 0.828 for primary melanoma detection. This melanoma autoantibody signature may prove valuable for the development of a diagnostic blood test for routine population screening that, when used in conjunction with current melanoma diagnostic techniques, could improve the early diagnosis of this malignancy and ultimately decrease the mortality rate of patients. © Zaenker et al.
Authors & Co-Authors
Gray, Elin Solomonovna
Australia, Perth
Edith Cowan University
Ziman, Mel
Australia, Perth
Edith Cowan University
Australia, Perth
The University of Western Australia
Statistics
Citations: 25
Authors: 2
Affiliations: 4
Identifiers
Doi:
10.18632/oncotarget.25669
ISSN:
19492553
Research Areas
Cancer
Health System And Policy
Study Design
Cross Sectional Study
Study Approach
Quantitative