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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The impact of single versus mixed schistosome species infections on liver, spleen and bladder morbidity within Malian children pre- and post-praziquantel treatment
BMC Infectious Diseases, Volume 10, Article 227, Year 2010
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Description
Background: In the developing world co-infections and polyparasitism within humans appear to be the rule rather than the exception, be it any combination of inter-specific and/or inter- and intra-Genera mixed infections. Mixed infections might generate synergistic or antagonistic interactions and thereby clinically affect individuals and/or impact parasite epidemiology.Methods: The current study uniquely assesses both Schistosoma mansoni- and Schistosoma haematobium-related morbidity of the liver and the bladder as assessed by ultrasound as well as spleen and liver morbidity through clinical exams. The impact of praziquantel (PZQ) treatment on such potential inter-specific schistosome interactions and resulting morbidity using uniquely detailed longitudinal data (pre- and one year post-PZQ treatment) arising from the National Schistosomiasis Control Program in three areas of Mali: Ségou, Koulikoro and Bamako, is also evaluated. At baseline, data were collected from up to 2196 children (aged 7-14 years), 844 of which were infected with S. haematobium only, 124 with S. mansoni only and 477 with both. Follow-up data were collected from up to 1265 children.Results: Results suggested lower liver morbidity in mixed compared to single S. mansoni infections and higher bladder morbidity in mixed compared to single S. haematobium infections. Single S. haematobium or S. mansoni infections were also associated with liver and spleen morbidity whilst only single S. haematobium infections were associated with bladder morbidity in these children (light S. haematobium infection OR: 4.3, p < 0.001 and heavy S. haematobium infection OR: 19, p < 0.001). PZQ treatment contributed to the regression of some of the forms of such morbidities.Conclusions: Whilst the precise biological mechanisms for these observations remain to be ascertained, the results illustrate the importance of considering mixed species infections in any analyses of parasite-induced morbidity, including that for the proposed Disability Adjusted Life Years (DALYs) revised estimates of schistosomiasis morbidity. © 2010 Koukounari et al; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2927598/bin/1471-2334-10-227-S1.DOC
Authors & Co-Authors
Koukounari, Artemis
United Kingdom, London
Imperial College London
Donnelly, Christl A.
United Kingdom, London
Imperial College London
Sacko, Moussa
Mali, Bamako
Institut National de Recherche en Sante Publique Mali
Kéïta, Adama Mamby
Mali, Bamako
Hopital National du Point g
Landouré, Aly
Mali, Bamako
Institut National de Recherche en Sante Publique Mali
Dembélé, Robert
Mali, Bamako
Ministère de la Santé
Bosqué-Oliva, Elisa
United Kingdom, London
Imperial College London
Gabrielli, Albis Francesco
Switzerland, Geneva
Organisation Mondiale de la Santé
Gouvras, Anouk N.
United Kingdom, London
Imperial College London
Traoré, Mamadou M.
Mali, Bamako
Institut National de Recherche en Sante Publique Mali
Fenwick, Alan
United Kingdom, London
Imperial College London
Webster, Joanne P.
United Kingdom, London
Imperial College London
Statistics
Citations: 54
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1186/1471-2334-10-227
e-ISSN:
14712334
Research Areas
Disability
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Mali