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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Evaluation of Mycobacterium tuberculosis-specific antibody responses in populations with different levels of exposure from Tanzania, Ethiopia, Brazil, and Denmark
Clinical Infectious Diseases, Volume 45, No. 5, Year 2007
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Description
Background. New, simple, and better-performing diagnostic tools are needed for the diagnosis of tuberculosis (TB). Much effort has been invested in developing an antibody-based test for TB, but to date, no such test has performed with sufficient sensitivity and specificity. A key question remaining is the extent to which the disappointing performance of current tests is associated with a high background prevalence of latent TB. Methods. We compared Mycobacterium tuberculosis-specific ESAT-6 and CFP-10 antibody responses in a total of 565 human serum samples from M. tuberculosis-uninfected donors and donors with latent infection, as well as samples from patients with active TB. Our study included samples from 4 countries, representing environments with low, intermediate, and high TB incidences. Results. We demonstrated significant increases in antibody levels in latently infected contacts, compared with M. tuberculosis-uninfected individuals, and in patients with active TB disease, compared with latently infected contacts. Furthermore, we found a striking increase in the magnitude of the antibody responses in samples obtained from infected Ethiopian individuals (with and without disease), compared with Danish and Brazilian infected individuals; this was presumably the result of higher exposure levels. Conclusions. Our study confirms the presence of ESAT-6 and CFP-10 antibodies in patients with TB, and we demonstrate that significant antibody responses are not restricted to active TB disease but can reflect latent infection, particularly in areas with high levels of exposure to M. tuberculosis. This finding is important for the understanding of the poor discriminatory power of current serodiagnostic tests in regions of endemicity, and it may have major implications on the future development of serologic tests. © 2007 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Hoff, Søren Tetens
Denmark, Copenhagen
Statens Serum Institut
Abebe, Markos
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Ravn, Pernille
Denmark, Hvidovre
Hvidovre Hospital
Range, Nyagosya Segere
Tanzania, Tanga
National Institute for Medical Research Tanga
Malenganisho, Wabyahe
Tanzania, Tanga
National Institute for Medical Research Tanga
Rodriques, Denise S.
Brazil, Sao Paulo
Instituto Clemente Ferreira
Brazil, Sao Paulo
Universidade Federal de São Paulo
Kállas, Èsper Georges
Brazil, Sao Paulo
Universidade Federal de São Paulo
Soborg, Christian
Denmark, Copenhagen
Rigshospitalet
Doherty, Timothy Mark
Denmark, Copenhagen
Statens Serum Institut
Andersen, Peter Lawætz
Denmark, Copenhagen
Statens Serum Institut
Weldingh, Karin N.
Denmark, Copenhagen
Statens Serum Institut
Statistics
Citations: 66
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1086/520662
ISSN:
10584838
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Ethiopia
Tanzania