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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Sexually transmitted disease and HIV prevalence and risk factors in concentrated and generalized HIV epidemic settings
AIDS, Volume 21, No. SUPPL. 2, Year 2007
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Description
BACKGROUND: In many developing countries, the threat of nascent HIV epidemics expanding rapidly requires immediate and appropriate HIV prevention activities. Inexpensive and sustainable interventions are especially relevant in resource-constrained environments. In 2001, we assessed the prevalence and behavioral risk of sexually transmitted disease (STD) and HIV among at-risk populations in five developing countries in preparation for a community-randomized controlled trial, the NIMH Collaborative HIV/STD Prevention Trial. METHODS: Using a standardized protocol, more than 1000 participants in each country (China, India, Peru, Russia, and Zimbabwe) were selected by random sampling methods, completed a behavioral risk assessment, and provided biological specimens using a common laboratory protocol. Sample characteristics were studied within each country, and risk factors for HIV/STD acquisition were evaluated using logistic regression models. RESULTS: HIV rates were low (< 1%) in China, India, Peru, and Russia but were high (26%) in rural Zimbabwe. STDs were generally twice as common in women as men, and serological evidence of herpes simplex virus type 2 infection was the most frequently detected STD. Behavioral data showed high rates of multiple partners in the Russian sample, and very low condom use rates in India and China. Among participants who reported ever having sex, female sex and having two or more sex partners were the factors most frequently associated with an increased risk of prevalent STD. CONCLUSION: Behavioral or biological risks were of sufficient magnitude in the locations selected in China, Russia, and Zimbabwe to implement the community-based randomized trial. Higher-risk subsets of community residents in India and Peru were identified before beginning the Trial. © 2007 Lippincott Williams & Wilkins, Inc.
Authors & Co-Authors
Cáceres, Carlos F.
Peru, Lima
Universidad Peruana Cayetano Heredia
Celentano, David D.
United States, Baltimore
Johns Hopkins University
Coates, Thomas J.
United States, Los Angeles
David Geffen School of Medicine at Ucla
Hartwell, Tyler D.
United States, Research Triangle Park
Rti International
Kasprzyk, Danuta
Unknown Affiliation
Kelly, Jeffrey A.
United States, Milwaukee
Medical College of Wisconsin
Kozlov, Andrei P.
Russian Federation, Saint Petersburg
Saint Petersburg State University
Pequegnat, Willo
United States, Bethesda
Instituto Nacional de la Salud Mental
Rotheram-Borus, Mary Jane Ane
United States, Los Angeles
University of California, Los Angeles
Solomon, Suniti S.
India
Yrg Centre for Aids Research and Education Yrg Care
Woelk, Godfrey B.
Zimbabwe, Harare
University of Zimbabwe
Wu, Zunyou
China, Beijing
Chinese Center for Disease Control and Prevention
Statistics
Citations: 43
Authors: 12
Affiliations: 11
Identifiers
Doi:
10.1097/01.aids.0000299414.60022.1b
Research Areas
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Zimbabwe
Participants Gender
Male
Female