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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Hantaviruses in Africa
Virus Research, Volume 187, Year 2014
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Description
This paper summarizes the progress in the search for hantaviruses and hantavirus infections in Africa. After having collected molecular evidence of an indigenous African hantavirus in 2006, an intensive investigation for new hantaviruses has been started in small mammals. Various novel hantaviruses have been molecularly identified not only in rodents but also in shrews and bats. In addition, the first African hantavirus, Sangassou virus, has been isolated and functionally characterized in cell culture. Less is known about the ability of these hantaviruses to infect humans and to cause diseases. To date, no hantavirus genetic material could be amplified from patients' specimens collected in Africa. Serological studies in West Africa, based on a battery of screening and confirmatory assays, led to the detection of hantavirus antibodies in the human population and in patients with putative hantavirus disease. In addition to this overview, we present original data from seroepidemiological and field studies conducted in the Southern part of Africa. A human seroprevalence rate of 1.0% (n=. 1442) was detected in the South African Cape Region whereas no molecular evidence for the presence of hantavirus was found in 2500 small animals trapped in South Africa and Namibia. © 2014 Elsevier B.V.
Authors & Co-Authors
Witkowski, P. T.
Germany, Berlin
Charité – Universitätsmedizin Berlin
Klempa, Boris
Germany, Berlin
Charité – Universitätsmedizin Berlin
Slovakia, Bratislava
Institute of Virology Slovak Academy of Sciences
Ithete, Ndapewa L.
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Auste, Brita
Germany, Berlin
Charité – Universitätsmedizin Berlin
Mfune, John Kazgeba Elijah
Namibia, Windhoek
University of Namibia
Hoveka, Julia
Namibia, Windhoek
University of Namibia
Matthee, Sonja
South Africa, Stellenbosch
Stellenbosch University
Preiser, Wolfgang
South Africa, Cape Town
Stellenbosch University, Faculty of Medicine and Health Sciences
Kruger, Detlev H.
Germany, Berlin
Charité – Universitätsmedizin Berlin
Statistics
Citations: 48
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1016/j.virusres.2013.12.039
ISSN:
01681702
e-ISSN:
18727492
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Multi-countries
Namibia
South Africa