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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
High-affinity memory B cells induced by SARS-CoV-2 infection produce more plasmablasts and atypical memory B cells than those primed by mRNA vaccines
Cell Reports, Volume 37, No. 2, Article 109823, Year 2021
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Description
Although both infections and vaccines induce memory B cell (MBC) populations that participate in secondary immune responses, the MBCs generated in each case can differ. Here, we compare SARS-CoV-2 spike receptor binding domain (S1-RBD)-specific primary MBCs that form in response to infection or a single mRNA vaccination. Both primary MBC populations have similar frequencies in the blood and respond to a second S1-RBD exposure by rapidly producing plasmablasts with an abundant immunoglobulin (Ig)A+ subset and secondary MBCs that are mostly IgG+ and cross-react with the B.1.351 variant. However, infection-induced primary MBCs have better antigen-binding capacity and generate more plasmablasts and secondary MBCs of the classical and atypical subsets than do vaccine-induced primary MBCs. Our results suggest that infection-induced primary MBCs have undergone more affinity maturation than vaccine-induced primary MBCs and produce more robust secondary responses. © 2021 The Authors
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC8463313/bin/mmc1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8463313/bin/mmc2.pdf
Authors & Co-Authors
Rhein, Joshua R.
United States, Minneapolis
University of Minnesota Medical School
Schacker, Timothy W.
United States, Minneapolis
University of Minnesota Medical School
Khoruts, Alexander
United States, Minneapolis
University of Minnesota Medical School
Statistics
Citations: 66
Authors: 3
Affiliations: 1
Identifiers
Doi:
10.1016/j.celrep.2021.109823
ISSN:
22111247