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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Distinct roles for FOXP3
+
and FOXP32 CD4
+
T cells in regulating cellular immunity to uncomplicated and severe plasmodium falciparum malaria
PLoS Pathogens, Volume 5, No. 4, Year 2009
Notification
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Description
Failure to establish an appropriate balance between pro- and anti-inflammatory immune responses is believed to contribute to pathogenesis of severe malaria. To determine whether this balance is maintained by classical regulatory T cells (CD4+ FOXP3+CD127-/low; Tregs) we compared cellular responses between Gambian children (n = 124) with severe Plasmodium falciparum malaria or uncomplicated malaria infections. Although no significant differences in Treg numbers or function were observed between the groups, Treg activity during acute disease was inversely correlated with malaria-specific memory responses detectable 28 days later. Thus, while Tregs may not regulate acute malarial inflammation, they may limit memory responses to levels that subsequently facilitate parasite clearance without causing immunopathology. Importantly, we identified a population of FOXP32 -, CD45RO+ CD4+ T cells which coproduce IL-10 and IFN-γ. These cells are more prevalent in children with uncomplicated malaria than in those with severe disease, suggesting that they may be the regulators of acute malarial inflammation. © 2009 Walther et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2658808/bin/ppat.1000364.s001.tif
Authors & Co-Authors
Walther, Michael
Unknown Affiliation
Jeffries, David J.
Unknown Affiliation
Finney, Olivia C.
Unknown Affiliation
Njie, Madi
Unknown Affiliation
Ebonyi, Augustine Odo
Unknown Affiliation
Deininger, Susanne
Unknown Affiliation
Lawrence, Emma
Unknown Affiliation
Ngwa-Amambua, Alfred
Unknown Affiliation
Jayasooriya, Shamanthi
Unknown Affiliation
Cheeseman, Ian H.
Unknown Affiliation
Gomez-Escobar, Natalia
Unknown Affiliation
Okebe, Joseph U.
Unknown Affiliation
Conway, David J.
Unknown Affiliation
Riley, Eleanor M.
Unknown Affiliation
Statistics
Citations: 212
Authors: 14
Affiliations: 4
Identifiers
Doi:
10.1371/journal.ppat.1000364
ISSN:
15537366
e-ISSN:
15537374
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study