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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Comparative biochemical and molecular evaluation of swarming of Proteus and effects of anti-swarm agents
African Journal of Biotechnology, Volume 3, No. 1, Year 2004
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Description
In addition to inadequate understanding of swarming motility and virulence of Proteus, there is paucity of information on the relative effectiveness of the various anti-swarm agents. The anti-swarming effects of urea, sodium dodecylsulphate (SDS) and trihydroxymethylglycine (Tris) on 40 clinical isolates of Proteus Spp. were comparatively investigated and plasmids associated with swarming were characterized. The three substances elicited a comparable concentration-dependent anti-swarming property at 0.25 - 1.25% on nutrient agar. Anti-swarm agents displayed heterogeneity in their ability to cause significant decreases in the expression of virulence factors. Swarm motility was further found to be strongly associated with the expression of virulence factors in these strains. Of the Proteus strains tested, 32 were found to harbour 1 - 4 plasmids of size ranging from 6.0 - 33.5 kb. Plasmid curing resulted in loss of swarming in 65.6% of these strains. In order to reduce the risk of infection with virulent Proteus strains, the laboratory use of urea and SDS is suggested. © 2004 Academic Journals.
Authors & Co-Authors
Iwalokun, Bamidele Abiodun
Nigeria, Lagos
Lagos State University
Olukosi, Yetunde Adeola
Nigeria, Yaba
Nigerian Institute of Medical Research
Adejoro, A.
Nigeria, Lagos
Lagos State University
Olaye, J. A.
Nigeria, Lagos
Lagos State University
Fashade, O.
Nigeria, Lagos
Lagos State University
Statistics
Citations: 12
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.5897/AJB2004.000-2018
ISSN:
16845315
e-ISSN:
16845315
Research Areas
Genetics And Genomics