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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Storage lipid studies in tuberculosis reveal that foam cell biogenesis is disease-specific
PLoS Pathogens, Volume 14, No. 8, Article 1007223, Year 2018
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Description
Foam cells are lipid-laden macrophages that contribute to the inflammation and tissue damage associated with many chronic inflammatory disorders. Although foam cell biogenesis has been extensively studied in atherosclerosis, how these cells form during a chronic infectious disease such as tuberculosis is unknown. Here we report that, unlike the cholesterol-laden cells of atherosclerosis, foam cells in tuberculous lung lesions accumulate triglycerides. Consequently, the biogenesis of foam cells varies with the underlying disease. In vitro mechanistic studies showed that triglyceride accumulation in human macrophages infected with Mycobacterium tuberculosis is mediated by TNF receptor signaling through downstream activation of the caspase cascade and the mammalian target of rapamycin complex 1 (mTORC1). These features are distinct from the known biogenesis of atherogenic foam cells and establish a new paradigm for non-atherogenic foam cell formation. Moreover, they reveal novel targets for disease-specific pharmacological interventions against maladaptive macrophage responses. © 2018 Guerrini et al.
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Authors & Co-Authors
Prideaux, Brendan
United States, Newark
Public Health Research Institute
Blanc, Landry
United States, Newark
Public Health Research Institute
Bruiners, Natalie
United States, Newark
Public Health Research Institute
Chen, Peiyu
United States, Newark
Public Health Research Institute
Subbian, Selvakumar
United States, Newark
Public Health Research Institute
Via, L. E.
United States, Bethesda
National Institutes of Health Nih
Barry, Clifton Earl
United States, Bethesda
National Institutes of Health Nih
Dartois, Véronique A.
United States, Newark
Public Health Research Institute
Gennaro, Maria Laura
United States, Newark
Public Health Research Institute
Statistics
Citations: 61
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1371/journal.ppat.1007223
ISSN:
15537366