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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Antibiotic consumption as a driver for resistance in Staphylococcus aureus and Escherichia coli within a developing region
American Journal of Infection Control, Volume 38, No. 3, Year 2010
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Description
Background: This study aimed to provide insight into possible antibiotic drivers of methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli resistant to third-generation cephalosporins (3GCREC) in southern and eastern Mediterranean institutions. Methods: MRSA and 3GCREC susceptibility proportions from 19 regional hospitals, previously published by the ARMed project, were correlated with antibiotic use data from the same institutions. Results: Hospitals reporting below-median MRSA proportions had significantly lower total antibiotic use. MRSA proportions increased with greater use of carbapenems (P = .04). In multivariate analysis, a positive correlation was identified with the use of carbapenems (P = .002), combination penicillins (P = .018), and aminoglycosides (P = .014). No difference was ascertained between 3GCREC proportions and total antibiotic use. In multivariate linear regression, a correlation was identified only for 3GCREC (P = .005), but a negative association was evident for beta-lactamase-resistant penicillins (P = .010) and first-generation cephalosporins (P = .012). Conclusions: The results suggest an association between resistance and antibiotic use, especially for carbapenems and third-generation cephalosporins. These data support the urgent implementation of antibiotic stewardship initiatives in hospitals in developing countries that focus on more judicious use of broad-spectrum formulations. © 2010 Association for Professionals in Infection Control and Epidemiology, Inc.
Authors & Co-Authors
Borg, Michael A.
Malta, Valletta
Mater Dei Hospital
Zarb, Peter
Malta, Valletta
Mater Dei Hospital
Scicluna, Elizabeth Anne
Malta, Valletta
Mater Dei Hospital
Rasslan, Ossama
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Gu¨r, Deniz
Turkey, Ankara
Hacettepe Üniversitesi
Ben-Redjeb, Saïda B.
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Elnasser, Ziad Ali
Jordan, Irbid
Jordan University of Science and Technology
Daoud, Ziad D.
Lebanon, Beirut
Saint George Hospital University Medical Center
Statistics
Citations: 30
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1016/j.ajic.2009.07.010
ISSN:
01966553