Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Determinants of per-coital-act HIV-1 infectivity among African HIV-1-serodiscordant couples
Journal of Infectious Diseases, Volume 205, No. 3, Year 2012
Notification
URL copied to clipboard!
Description
Background. Knowledge of factors that affect per-act infectivity of human immunodeficiency virus type 1 (HIV-1) is important for designing HIV-1 prevention interventions and for the mathematical modeling of the spread of HIV-1. Methods. We analyzed data from a prospective study of African HIV-1-serodiscordant couples. We assessed transmissions for linkage within the study partnership, based on HIV-1 sequencing. The primary exposure measure was the HIV-1-seropositive partners' reports of number of sex acts and condom use with their study partner. Results. Of 3297 couples experiencing 86 linked HIV-1 transmissions, the unadjusted per-act risks of unprotected male-to-female (MTF) and female-to-male (FTM) transmission were 0.0019 (95% confidence interval [CI],. 0010-.0037) and 0.0010 (95% CI,. 00060-.0017), respectively. After adjusting for plasma HIV-1 RNA of the HIV-1-infected partner and herpes simplex virus type 2 serostatus and age of the HIV-1-uninfected partner, we calculated the relative risk (RR) for MTF versus FTM transmission to be 1.03 (P =. 93). Each log 10 increase in plasma HIV-1 RNA increased the per-act risk of transmission by 2.9-fold (95% CI, 2.2-3.8). Self-reported condom use reduced the per-act risk by 78% (RR = 0.22 [95% CI,. 11-.42]). Conclusions. Modifiable risk factors for HIV-1 transmission were plasma HIV-1 RNA level and condom use, and, in HIV-1-uninfected partners, herpes simplex virus 2 infection, genital ulcers, Trichomonas vaginalis, vaginitis or cervicitis, and male circumcision. © The Author 2011. Published by Oxford University Press on behalf of the Infectious.
Authors & Co-Authors
Hughes, James P.
United States, Seattle
University of Washington
United States, Seattle
Fred Hutchinson Cancer Research Center
Baeten, Jared M.
United States, Seattle
University of Washington
Lingappa, Jairam R.
United States, Seattle
University of Washington
Magaret, Amalia Meier
United States, Seattle
University of Washington
Wald, Anna
United States, Seattle
University of Washington
De Bruyn, Guy
South Africa, Johannesburg
University of the Witwatersrand
Kiarie, James Njogu
Kenya, Nairobi
Kenyatta National Hospital
Inambao, Mubiana
Zambia, Ndola
Rwanda Zambia Hiv Research Group
Kilembe, William
Zambia, Ndola
Rwanda Zambia Hiv Research Group
Farquhar, Carey
United States, Seattle
University of Washington
Celum, Connie L.
United States, Seattle
University of Washington
Statistics
Citations: 332
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1093/infdis/jir747
ISSN:
00221899
Research Areas
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cohort Study
Participants Gender
Male
Female