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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex
Brain Imaging and Behavior, Volume 11, No. 5, Year 2017
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Description
The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders. © 2016, The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC5540813/bin/11682_2016_9629_MOESM1_ESM.pdf
Authors & Co-Authors
Guadalupe, Tulio M.
Netherlands, Nijmegen
Max Planck Institute for Psycholinguistics
Netherlands, Nijmegen
International Max Planck Research School for Language Sciences
Mathias, Samuel R.
United States, New Haven
Yale School of Medicine
van Erp, Theo G.M.
United States, Irvine
University of California, Irvine
Whelan, Christopher D.
United States, Los Angeles
Keck School of Medicine of Usc
Ireland, Dublin
Royal College of Surgeons in Ireland
Zwiers, Marcel Peter
Netherlands, Nijmegen
Donders Institute for Brain, Cognition and Behaviour
Abe, Yoshinari
Japan, Kyoto
Graduate School of Medical Science
Abramovic, Lucija
Netherlands, Utrecht
University Medical Center Utrecht
Agartz, Ingrid A.
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Diakonhjemmet Sykehus
Sweden, Stockholm
Karolinska Institutet
Andreassen, Ole Andreas
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Oslo Universitetssykehus
Arias-Vásquez, Alejandro
Netherlands, Nijmegen
Radboud University Medical Center
Aribisala, Benjamin Segun
Nigeria, Lagos
Lagos State University
United Kingdom, Edinburgh
The University of Edinburgh
Armstrong, Nicola J.
Australia, Sydney
Unsw Sydney
Australia, Perth
Murdoch University
Arolt, Volker
Germany, Munster
University of Münster
Artiges, Éric
France, Gif-sur-yvette
Université Paris-saclay
Ayesa-Arriola, Rosa
Spain, Santander
Universidad de Cantabria
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Baboyan, Vatche George
United States, Los Angeles
Keck School of Medicine of Usc
Banaschewski, Tobias J.
Germany, Mannheim
Zentralinstitut Für Seelische Gesundheit
Barker, Gareth J.
United Kingdom, London
King's College London
Bastin, Mark E.
United Kingdom, Edinburgh
The University of Edinburgh
Baune, Bernhard T.
Australia, Adelaide
Adelaide Medical School
Blangero, John C.
United States, San Antonio
Texas Biomedical Research Institute
Bokde, Arun L.W.
Ireland, Dublin
Trinity College Dublin
Boedhoe, Premika S.W.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Bose, Anushree
India, Bengaluru
National Institute of Mental Health and Neuro Sciences
Brem, Silvia
Switzerland, Zurich
Universität Zürich
Switzerland, Zurich
Neuroscience Center Zurich
Brodaty, Henry
Australia, Sydney
Unsw Sydney
Bromberg, Uli
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Brooks, Samantha Jane
South Africa, Cape Town
University of Cape Town
Büchel, Christian
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Buitelaar, Jan K.
Netherlands, Nijmegen
Radboud University Medical Center
Netherlands, Nijmegen
Radboud Universiteit
Calhoun, Vince D.
United States, Albuquerque
The University of new Mexico
United States, Albuquerque
The Mind Research Network
Cannon, Dara M.
Ireland, Galway
University of Galway
Cattrell, Anna
United Kingdom, London
Faculty of Life Sciences & Medicine
Cheng, Yuqi
China, Kunming
Kunming Medical University
Conrod, Patricia J.
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
United Kingdom, London
King's College London
Conzelmann, Annette
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Germany, Tubingen
Eberhard Karls Universität Tübingen
Corvin, Aiden P.
Ireland, Dublin
Trinity College Dublin
Crespo-Facorro, Benedicto
Spain, Santander
Universidad de Cantabria
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Crivello, Fabrice
France, Bordeaux
Université de Bordeaux
Dannlowski, Udo
Germany, Munster
University of Münster
Germany, Marburg
Philipps-universität Marburg
de Zubicaray, Greig I.
Australia, Brisbane
Queensland University of Technology
de Zwarte, Sonja M.C.
Netherlands, Utrecht
University Medical Center Utrecht
Deary, Ian J.
United Kingdom, Edinburgh
The University of Edinburgh
Desrivières, Sylvane
United Kingdom, London
Faculty of Life Sciences & Medicine
Doan, Nhat Trung
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Oslo Universitetssykehus
Donohoe, Gary J.
Ireland, Galway
University of Galway
Ireland, Dublin
Trinity College Dublin
Dørum, Erlend S.
Norway, Oslo
Oslo Universitetssykehus
Norway, Oslo
Universitetet I Oslo
Ehrlich, Stefan
Germany, Dresden
Medizinische Fakultät Carl Gustav Carus
United States, Boston
Massachusetts General Hospital
Espeseth, Thomas
Norway, Oslo
Oslo Universitetssykehus
Norway, Oslo
Universitetet I Oslo
Fernández, Guillén
Netherlands, Nijmegen
Radboud University Medical Center
Netherlands, Nijmegen
Radboud Universiteit
Flor, Herta
Germany, Mannheim
Zentralinstitut Für Seelische Gesundheit
Fouché, Jean Paul
South Africa, Cape Town
University of Cape Town
Frouin, Vincent
France, Gif-sur-yvette
Neurospin
Fukunaga, Masaki
Japan, Okazaki
National Institutes of Natural Sciences - National Institute for Physiological Sciences
Gallinat, Jürgen
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Garavan, Hugh P.
United States, Burlington
The University of Vermont
Gill, Michael J.
Ireland, Dublin
Trinity College Dublin
Suarez, Andrea Gonzalez
Spain, Santander
Universidad de Cantabria
Spain, Madrid
Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas
Gowland, Penny Anne
United Kingdom, Nottingham
University of Nottingham
Grabe, Hans Jörgen
Germany, Greifswald
Universitätsmedizin Greifswald
Germany, Stralsund
Helios Hospital Stralsund
Grotegerd, Dominik
Germany, Munster
University of Münster
Gruber, Oliver
Germany, Gottingen
Universitätsmedizin Göttingen
Hagenaars, Saskia P.
United Kingdom, Edinburgh
The University of Edinburgh
Hashimoto, Ryota
Japan, Suita
United Graduate School of Child Development
Japan, Suita
Graduate School of Medicine
Hauser, Tobias U.
Switzerland, Zurich
Universität Zürich
United Kingdom, London
Wellcome Centre for Human Neuroimaging
Germany, Berlin
Max Planck Ucl Centre for Computational Psychiatry and Ageing Research
Heinz, Andreas
Germany, Berlin
Charité – Universitätsmedizin Berlin
Hibar, Derrek Paul
United States, Los Angeles
Keck School of Medicine of Usc
Hoekstra, Pieter J.
Netherlands, Groningen
Rijksuniversiteit Groningen
Hoogman, Martine
Netherlands, Nijmegen
Radboud University Medical Center
Howells, Fleur Margaret
South Africa, Cape Town
University of Cape Town
Hu, Hao
China, Shanghai
Shanghai Mental Health Center
Hulshoff Pol, Hilleke E.
Netherlands, Utrecht
University Medical Center Utrecht
Huyser, Chaim
Netherlands, Amsterdam
De Bascule
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Ittermann, Bernd
Germany, Braunschweig
Physikalisch-technische Bundesanstalt
Jahanshad, Neda
United States, Los Angeles
Keck School of Medicine of Usc
Jönsson, Erik Gunnar
Sweden, Stockholm
Karolinska Institutet
Norway, Oslo
Universitetet I Oslo
Jurk, Sarah
Germany, Dresden
Technische Universität Dresden
Kahn, René S.
Netherlands, Utrecht
University Medical Center Utrecht
Kelly, Sinéad M.
United States, Los Angeles
Keck School of Medicine of Usc
Kraemer, Bernd
Germany, Gottingen
Universitätsmedizin Göttingen
Kugel, Harald
Germany, Munster
University of Münster
Kwon, Junsoo
South Korea, Seoul
Seoul National University College of Medicine
South Korea, Seoul
Seoul National University
Lemaître, Hervé S.
France, Gif-sur-yvette
Université Paris-saclay
Lesch, Klaus Peter
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Netherlands, Maastricht
Universiteit Maastricht
Lochner, Christine
South Africa, Tygerberg
South African Medical Research Council
Luciano, Michelle
United Kingdom, Edinburgh
The University of Edinburgh
Marquand, Andre F.
Netherlands, Nijmegen
Donders Institute for Brain, Cognition and Behaviour
United Kingdom, London
King's College London
Martin, Nicholas G.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Martínez-Zalacaín, Ignacio
Spain, Hospitalet de Llobregat
Institut D'investigació Biomedica de Bellvitge
Martinot, Jean Luc
France, Gif-sur-yvette
Université Paris-saclay
Mataix-Cols, David
Sweden, Stockholm
Karolinska Institutet
Mather, Karen A.
Australia, Sydney
Unsw Sydney
McDonald, Colm D.
Ireland, Galway
University of Galway
McMahon, Katie L.
Australia, Brisbane
The University of Queensland
Medland, Sarah E.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Menchón, Jose M.
Spain, Hospitalet de Llobregat
Institut D'investigació Biomedica de Bellvitge
Spain, Madrid
Instituto de Salud Carlos Iii
Spain, Barcelona
Universitat de Barcelona
Morris, Derek W.
Ireland, Galway
University of Galway
Mothersill, David O.
Ireland, Dublin
Trinity College Dublin
Ireland, Galway
University of Galway
Muñoz Maniega, Susana
United Kingdom, Edinburgh
The University of Edinburgh
Mwangi, Benson I.
United States, Houston
University of Texas Medical School at Houston
Nakamae, Takashi
Japan, Kyoto
Graduate School of Medical Science
Japan, Kyoto
Advanced Telecommunications Research Institute International Atr
Nakao, Tomohiro
Japan, Fukuoka
Graduate School of Medical Sciences
Nees, Frauke
Germany, Mannheim
Zentralinstitut Für Seelische Gesundheit
Nordvik, Jan Egil
Unknown Affiliation
Opel, Nils
Germany, Munster
University of Münster
Ophoff, R. A.
Netherlands, Utrecht
University Medical Center Utrecht
United States, Los Angeles
University of California, Los Angeles
Paillère-Martinot, Marie Laure
France, Gif-sur-yvette
Université Paris-saclay
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Papadopoulos-Orfanos, Dimitri
France, Gif-sur-yvette
Neurospin
Paus, Tomáš
Canada, Toronto
Rotman Research Institute
Poustka, Luise
Germany, Mannheim
Zentralinstitut Für Seelische Gesundheit
Austria, Vienna
Medizinische Universität Wien
Reddy, Yemmigannur Chandrashekhar Janardhan
India, Bengaluru
National Institute of Mental Health and Neuro Sciences
Rentería, Miguel E.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Roiz-Santiáñez, Roberto
Spain, Santander
Universidad de Cantabria
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Roos, Annerine
South Africa, Tygerberg
South African Medical Research Council
Royle, Natalie A.
United Kingdom, Edinburgh
The University of Edinburgh
Sachdev, Perminder S.
Australia, Sydney
Unsw Sydney
Schmaal, Lianne
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Schumann, Gunter
United Kingdom, London
Faculty of Life Sciences & Medicine
Shumskaya, Elena
Netherlands, Nijmegen
Donders Institute for Brain, Cognition and Behaviour
Netherlands, Nijmegen
Radboud University Medical Center
Smolka, Michael N.
Germany, Dresden
Technische Universität Dresden
Soares, Jair C.
United States, Houston
University of Texas Health Science Center at Houston
Soriano-Mas, Carles
Spain, Hospitalet de Llobregat
Institut D'investigació Biomedica de Bellvitge
Spain, Madrid
Instituto de Salud Carlos Iii
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Stein, Dan J.
South Africa, Tygerberg
South African Medical Research Council
Strike, Lachlan T.
Australia, Brisbane
The University of Queensland
Toro, Roberto
France, Paris
Institut Pasteur, Paris
Turner, Jessica A.
United States, Albuquerque
The Mind Research Network
United States, Atlanta
Georgia State University
Uhlmann, Anne
South Africa, Cape Town
University of Cape Town
Hernández, Maria Valdés
United Kingdom, Edinburgh
The University of Edinburgh
Van Den Heuvel, Odile A.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
van der Meer, Dennis
Netherlands, Groningen
Rijksuniversiteit Groningen
van Haren, Neeltje E.M.
Netherlands, Utrecht
University Medical Center Utrecht
Veltman, Dick J.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Venkatasubramanian, Ganesan
India, Bengaluru
National Institute of Mental Health and Neuro Sciences
Vuletic, Daniella
South Africa, Cape Town
University of Cape Town
Walitza, Susanne
Switzerland, Zurich
Universität Zürich
Switzerland, Zurich
Neuroscience Center Zurich
Walter, Henrik
Germany, Berlin
Charité – Universitätsmedizin Berlin
Walton, Esther
Germany, Dresden
Medizinische Fakultät Carl Gustav Carus
United States, Atlanta
Georgia State University
Wang, Zhen
China, Shanghai
Shanghai Mental Health Center
Wardlaw, Joanna M.
United Kingdom, Edinburgh
The University of Edinburgh
Wen, Wei
Australia, Sydney
Unsw Sydney
Westlye, Lars T.
Norway, Oslo
Oslo Universitetssykehus
Norway, Oslo
Universitetet I Oslo
Whelan, Robert
Ireland, Dublin
University College Dublin
Wittfeld, Katharina
Germany, Bonn
Deutsches Zentrum Für Neurodegenerative Erkrankungen
Wright, Margaret J.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Australia, Brisbane
The University of Queensland
Xu, Jian
China, Kunming
Kunming Medical University
Xu, Xiufeng
China, Kunming
Kunming Medical University
Yun, Je-yeon
South Korea, Seoul
Seoul National University Hospital
Thompson, Paul M.
United States, Los Angeles
Keck School of Medicine of Usc
Glahn, David C.
United States, New Haven
Yale University
Mazoyer, Bernard M.
France, Bordeaux
Université de Bordeaux
Fisher, Simon E.
Netherlands, Nijmegen
Max Planck Institute for Psycholinguistics
Netherlands, Nijmegen
Radboud Universiteit
Francks, Clyde
Netherlands, Nijmegen
Max Planck Institute for Psycholinguistics
Netherlands, Nijmegen
Radboud Universiteit
Statistics
Citations: 138
Authors: 152
Affiliations: 91
Identifiers
Doi:
10.1007/s11682-016-9629-z
ISSN:
19317557
Research Areas
Genetics And Genomics
Mental Health
Study Approach
Systematic review