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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Novel HPV-6 variants of human papillomavirus causing recurrent respiratory papillomatosis in southern Africa
Epidemiology and Infection, Volume 140, No. 6, Year 2012
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Description
There is currently no information regarding the genetic diversity of HPV-6 variants circulating in South Africa. The aim of this study was to determine the HPV-6 variants affecting patients with recurrent respiratory papillomatosis, to determine whether mutations correlate with disease severity and identify molecular determinants of virulence with prognostic relevance. HPV-6 variants were identified based on genome changes within the 712-991 bp region encompassing the non-coding region (URR) of the genome, with variations in length resulting from insertions and duplications, and the 453-bp gene encoding the E6 protein. Based on manual comparison of sequence data from the URR, the isolates were identified as HPV-6a and HPV-6vc variants. Three novel HPV-6 variants were identified: one based on a mutation in the E6 region; two based on changes in the URR including a unique substitution detected in three isolates and an insertion and 170-bp duplication in the URR genome in one patient, who had clinical features of severe disease. © 2011 Cambridge University Press.
Authors & Co-Authors
Combrinck, Catharina E.
South Africa, Bloemfontein
University of the Free State
Seedat, R. Y.
South Africa, Bloemfontein
University of the Free State
Randall, C.
South Africa, Bloemfontein
University of the Free State
Roodt, Y.
South Africa, Bloemfontein
University of the Free State
Burt, Felicity Jane
South Africa, Bloemfontein
University of the Free State
South Africa, Bloemfontein
National Health Laboratory Service Universitas
Statistics
Citations: 5
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1017/S0950268811001580
ISSN:
09502688
e-ISSN:
14694409
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Study Locations
South Africa