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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Fasciola gigantica: Evaluation of the effect of phenyl vinyl sulfone in vitro
Experimental Parasitology, Volume 119, No. 1, Year 2008
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Description
Phenyl vinyl sulfone is a synthetic inhibitor of cysteine protease and has antihelminthic and antiprotozoal properties. Phenyl vinyl sulfone was assayed in vitro for antifasciola activity against adult Fasciola gigantica worms using a well-established culture medium. Worms were treated with phenyl vinyl sulfone for incubation periods ranging from 0 to 12 h and its activity was assessed in terms of viability, motility and death of worms. Phenyl vinyl sulfone exhibited a minimum effective concentration of 50 ppm after 12 h. Three hundred parts per million concentrations were most potent causing immediate death of adult flukes in vitro. Histopathological studies showed that there was tegumental flattening, rupture of vesicles, and spine loss. Marked reduction in size and number of ova and sperms in the convoluted tubules of the reproductive organs was observed in comparison to the untreated control group. In conclusion, phenyl vinyl sulfone shows potent activity against F. gigantica in vitro, and the authors recommend carrying out more studies to detect its efficacy in vivo. © 2008 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Helmy, Moshira M.F.
Egypt, 6th October
Misr University for Science and Technology
Fahmy, Zeinab H.
Egypt, Giza
Theodor Bilharz Research Institute
Sabry, Hoda Y.
Egypt, Giza
Theodor Bilharz Research Institute
Statistics
Citations: 15
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1016/j.exppara.2008.01.002
ISSN:
00144894
e-ISSN:
10902449
Research Areas
Sexual And Reproductive Health
Study Design
Randomised Control Trial