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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Rodent hair is a Poor biomarker for internal manganese exposure
Food and Chemical Toxicology, Volume 157, Article 112555, Year 2021
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Description
Hair is used as a biomarker of manganese (Mn) exposure, yet there is limited evidence to support its utility to quantify internal vs external Mn exposure. C57BL/6 J mice and Sprague-Dawley rats were exposed in two blocks of 3 subcutaneous injections every 3 days starting on day 0 or 20. The control group received two blocks of saline (vehicle); Treatment A received the first block as Mn (50 mg/kg MnCl2 tetrahydrate), with the second block as either methylmercury (MeHg at 2.6 or 1.3 mg/kg) for mice or vehicle for rats; and Treatment B received Mn for both blocks. Hair was collected on days 0 and 60 from all treatment groups and Mn quantified by inductively coupled plasma-mass spectrometry (ICP-MS) and total Hg by Direct Mercury Analyzer (DMA). No correlation between internal Mn dose and hair Mn was observed, whereas hair Hg was significantly elevated in MeHg exposed vs non-exposed mice. Whole body Mn content at day 60 was quantified postmortem by neutron activation analysis, which detected significantly elevated Mn for Treatment B in mice and rats. Overall, we find no evidence to support the use of hair as a valid biomarker for internal exposure to Mn at a neurotoxic level. © 2021 Elsevier Ltd
Authors & Co-Authors
Morcillo, Patricia
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Akinyemi, Ayodele Jacob
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Nie, Linda Huiling
United States, West Lafayette
Purdue University
Áschner, Michael
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Bowman, Aaron B.
United States, West Lafayette
Purdue University
Statistics
Citations: 4
Authors: 5
Affiliations: 7
Identifiers
Doi:
10.1016/j.fct.2021.112555
ISSN:
02786915
Study Design
Randomised Control Trial