Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Bioactive 6 S-styryllactone constituents of polyalthia parviflora
Journal of Natural Products, Volume 77, No. 12, Year 2014
Notification
URL copied to clipboard!
Description
Parvistones A-E (1-5), five new styryllactones possessing a rare α,β-lactone moiety and a 6S configuration, were isolated from a methanolic extract of Polyalthia parviflora leaves. The structures and the absolute configuration of the isolates were elucidated using NMR spectroscopy, specific rotation, circular dichroism, and X-ray single-crystal analysis. Compounds 8, 9, 11, and 12 were isolated for the first time. The results were supported by comparing the data measured to those of 6R-styryllactones. Moreover, a plausible biogenetic pathway of the isolated compounds was proposed. The structure-activity relationship of the compounds in an in vitro anti-inflammatory assay revealed the 6S-styryllactones to be more potent than the 6R derivatives. However, the effect was opposite regarding their cytotoxic activity. In addition, 6S-styrylpyrones isolated showed more potent anti-inflammatory and cytotoxic activity when compared to the 1S-phenylpyranopyrones obtained. © 2014 The American Chemical Society and American Society of Pharmacognosy.
Authors & Co-Authors
Liou, Jingru
Taiwan, Kaohsiung
Kaohsiung Medical University
Wu, Tungying
Taiwan, Kaohsiung
Kaohsiung Medical University
Thăng, Trandinh
Viet Nam, Vinh
Vinh University
Hwang, Tsong Long
Taiwan, Taoyuan
Chang Gung University
Cheng, Yuanbin
Taiwan, Kaohsiung
Kaohsiung Medical University
Chiang, Michael Yen Nan
Taiwan, Kaohsiung
National Sun Yat-sen University
Lan, Yuhsuan
Taiwan, Taichung
China Medical University
El-Shazly, Mohamed
Taiwan, Kaohsiung
Kaohsiung Medical University
Wu, Shwu Li
Taiwan, Kaohsiung
National Kaohsiung University of Science and Technology
Beerhues, Ludger
Germany, Braunschweig
Technische Universität Braunschweig
Yuan, Shyng Shiou F.
Taiwan, Kaohsiung
Kaohsiung Medical University Chung-ho Memorial Hospital
Hou, Mingfeng
Taiwan, Kaohsiung
Kaohsiung Medical University Chung-ho Memorial Hospital
Chen, Shuli
Taiwan, Kaohsiung
Kaohsiung Medical University
Chang, Fangrong
Taiwan, Kaohsiung
Kaohsiung Medical University
Taiwan, Kaohsiung
Kaohsiung Medical University Chung-ho Memorial Hospital
Wu, Yangchang
Taiwan, Kaohsiung
Kaohsiung Medical University
Taiwan, Taichung
China Medical University
Taiwan, Taichung
China Medical University Hospital
Statistics
Citations: 34
Authors: 15
Affiliations: 9
Identifiers
Doi:
10.1021/np5004577
ISSN:
01633864