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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
Nature Genetics, Volume 45, No. 1, Year 2013
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Description
Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism. © 2013 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Horikoshi, Momoko
United Kingdom, Oxford
University of Oxford
Yaghootkar, Hanieh
United Kingdom, Plymouth
Plymouth University, Peninsula Schools of Medicine and Dentistry
Mook-Kanamori, Dennis Owen
Netherlands, Rotterdam
Erasmus Mc
Qatar, Doha
Weill Cornell Medicine-qatar
Sovio, Ulla
United Kingdom, London
Imperial College London
United Kingdom, London
London School of Hygiene & Tropical Medicine
Taal, Hendrik Rob
Netherlands, Rotterdam
Erasmus Mc
Hennig, Branwen J.W.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Gambia, Banjul
Medical Research Council Laboratories Gambia
Bradfield, Jonathan P.
United States, Philadelphia
The Children's Hospital of Philadelphia
St Pourcain, Beate
United Kingdom, Bristol
University of Bristol
Evans, David M.
United Kingdom, Bristol
University of Bristol
Charoen, Pimphen
United Kingdom, London
Imperial College London
Thailand, Nakhon Pathom
Mahidol University
Kaakinen, Marika A.
Finland, Oulu
Oulun Yliopisto
Cousminer, Diana L.
Finland, Helsinki
Helsingin Yliopisto
Lehtimäki, Terho J.
Finland, Tampere
Tampere University
Finland, Tampere
University Hospital of Tampere
Kreiner-Møller, Eskil
Denmark, Copenhagen
Københavns Universitet
Denmark, Hellerup
Gentofte Hospital
Warrington, Nicole M.
Australia, Perth
The University of Western Australia
Bustamante, Mariona
Spain, Barcelona
Instituto de Salud Global de Barcelona
Spain, Barcelona
Institut Municipal D'investigacio Medica
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Feenstra, Bjarke
Denmark, Copenhagen
Statens Serum Institut
Berry, Diane J.
United Kingdom, London
University College London
Thiering, Elisabeth
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Pfab, Thiemo
Germany, Berlin
Charité – Universitätsmedizin Berlin
Germany, Potsdam
Universität Potsdam
Barton, Sheila J.
United Kingdom, Southampton
University of Southampton
Shields, Beverley M.
United Kingdom, Exeter
University of Exeter
Kerkhof, Marjan
Netherlands, Groningen
Rijksuniversiteit Groningen
van Leeuwen, Elisabeth M.
Netherlands, Rotterdam
Erasmus Mc
Fulford, Anthony J.C.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Gambia, Banjul
Medical Research Council Laboratories Gambia
Kutalik, Zoltán
Switzerland, Lausanne
Université de Lausanne Unil
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Zhao, Jinghua
United Kingdom, Cambridge
Wellcome-mrc Institute of Metabolic Science
den Hoed, Marcel
United Kingdom, Cambridge
Wellcome-mrc Institute of Metabolic Science
Mahajan, Anubha
United Kingdom, Oxford
University of Oxford
Lindi, Virpi
Finland, Kuopio
Itä-suomen Yliopisto
Goh, Liang Kee
Singapore, Singapore City
Duke-nus Medical School
Singapore, Singapore City
National University of Singapore
Hottenga, Jouke Jan
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Wu, Ying
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Raitakari, Olli T.
Finland, Turku
Turun Yliopisto
Finland, Turku
Turun Yliopistollinen Keskussairaala
Harder, Marie Neergaard
Denmark, Copenhagen
Københavns Universitet
Meirhaeghe, Aline
France, Paris
Inserm
France, Lille
Institut Pasteur de Lille
France, Lille
Université de Lille
Ntalla, Ioanna
Greece, Athens
Harokopio University of Athens
Salem, Rany M.
United States, Boston
Boston Children's Hospital
United States, Cambridge
Broad Institute
United States, Boston
Harvard Medical School
Jameson, Karen A.
United Kingdom, Southampton
University of Southampton
Zhou, Kaixin
United Kingdom, Dundee
University of Dundee
Monies, Dorota Marta
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Lagou, Vasiliki
United Kingdom, Oxford
University of Oxford
Kirin, Mirna
United Kingdom, Edinburgh
The University of Edinburgh
Heikkinen, Jani
Finland, Helsinki
Helsingin Yliopisto
Adair, Linda S.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Alkuraya., Fowzan S.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Saudi Arabia, Riyadh
King Khaled Eye Specialist Hospital
Saudi Arabia, Riyadh
Alfaisal University
Al-Odaib, Ali Nasser
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Amouyel, Philippe
France, Paris
Inserm
France, Lille
Institut Pasteur de Lille
France, Lille
Université de Lille
Andersson, Ehm Astrid
Denmark, Copenhagen
Københavns Universitet
Bennett, Amanda J.
United Kingdom, Oxford
University of Oxford
Blakemore, Alexandra I.F.
United Kingdom, London
Imperial College London
Buxton, Jessica L.
United Kingdom, London
Imperial College London
Dallongeville, Jean
France, Paris
Inserm
France, Lille
Institut Pasteur de Lille
France, Lille
Université de Lille
Das, Shikta
United Kingdom, London
Imperial College London
de Geus, Eco J.C.N.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Estivill, Xavier
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Flexeder, Claudia
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Froguel, Philippe
France, Lille
Institut Pasteur de Lille
France, Lille
Université de Lille
United Kingdom, London
Imperial College London
Geller, Frank
Denmark, Copenhagen
Statens Serum Institut
Godfrey, Keith M.
United Kingdom, Southampton
University of Southampton
Gottrand, Frédéric
France, Lille
Université de Lille
Groves, Christopher James
United Kingdom, Oxford
University of Oxford
Hansen, Torben Frøstrup
Denmark, Copenhagen
Københavns Universitet
Denmark, Odense
Syddansk Universitet
Hirschhorn, Joel N.
United States, Boston
Boston Children's Hospital
United States, Cambridge
Broad Institute
United States, Boston
Harvard Medical School
Hofman, Albert
Netherlands, Rotterdam
Erasmus Mc
Hollegaard, Mads Vilhelm
Denmark, Copenhagen
Statens Serum Institut
Hougaard, David Michael
Denmark, Copenhagen
Statens Serum Institut
Hyppönen, Elina
United Kingdom, London
University College London
Inskip, Hazel M.
United Kingdom, Southampton
University of Southampton
Isaacs, Aaron J.
Netherlands, Rotterdam
Erasmus Mc
Netherlands, Leiden
Universiteit Leiden
Jörgensen, Torben J.
Denmark, Glostrup
Amtssygehuset I Glostrup
Denmark, Copenhagen
Københavns Universitet
Kanaka-Gantenbein, Christina
Greece, Athens
Aghia Sophia Children's Hospital
Kemp, John P.
United Kingdom, Bristol
University of Bristol
Kiess, Wieland
Germany, Leipzig
Universität Leipzig
Kilpeläinen, Tuomas Oskari
United Kingdom, Cambridge
Wellcome-mrc Institute of Metabolic Science
Finland, Kuopio
Itä-suomen Yliopisto
Denmark, Copenhagen
Københavns Universitet
Klopp, Norman
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Hannover
Hannover Medical School
Knight, Bridget Ann
United Kingdom, Exeter
University of Exeter
Kuzawa, Christopher W.
United States, Evanston
Northwestern University
McMahon, George
United Kingdom, Bristol
University of Bristol
Newnham, John P.
Australia, Perth
The University of Western Australia
Niinikoski, Harri
Finland, Turku
Turun Yliopisto
Oostra, Ben A.
Netherlands, Rotterdam
Erasmus Mc
Pedersen, Louise L.
Denmark, Copenhagen
Københavns Universitet
Denmark, Hellerup
Gentofte Hospital
Postma, Dirkje S.
Netherlands, Groningen
Rijksuniversiteit Groningen
Ring, Susan M.
United Kingdom, Bristol
University of Bristol
Rivadeneira, Fernando F.
Netherlands, Rotterdam
Erasmus Mc
Robertson, Neil R.
United Kingdom, Oxford
University of Oxford
Sébert, Sylvain P.
United Kingdom, London
Imperial College London
Finland, Oulu
Oulun Yliopisto
Simell, Olli G.
Finland, Turku
Turun Yliopisto
Slowinski, Torsten
Germany, Berlin
Charité – Universitätsmedizin Berlin
Tiesler, Carla M.T.
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Ludwig-maximilians-universität München
Tönjes, Anke
Germany, Leipzig
Universität Leipzig
Vaag, Allan Arthur
Denmark, Copenhagen
Rigshospitalet
Denmark, Herlev
Steno Diabetes Center Copenhagen
Viikari, Jorma S.A.
Finland, Turku
Turun Yliopisto
Vink, Jacqueline M.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Vissing, Nadja Hawwa
Denmark, Copenhagen
Københavns Universitet
Denmark, Hellerup
Gentofte Hospital
Wareham, Nicholas J.
United Kingdom, Cambridge
Wellcome-mrc Institute of Metabolic Science
Willemsen, Gonneke A.H.M.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Witte, Daniel R.
Denmark, Herlev
Steno Diabetes Center Copenhagen
Zhang, Haitao
United States, Philadelphia
The Children's Hospital of Philadelphia
Wilson, James F.
United Kingdom, Edinburgh
The University of Edinburgh
United Kingdom, Edinburgh
Western General Hospital
Stumvoll, Michael W.
Germany, Leipzig
Universität Leipzig
Prentice, Andrew M.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Gambia, Banjul
Medical Research Council Laboratories Gambia
Meyer, Brian Francis
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Pearson, Ewan Robert
United Kingdom, Dundee
University of Dundee
Boreham, Colin Ag G.
Ireland, Dublin
University College Dublin
Cooper, Cyrus C.
United Kingdom, Southampton
University of Southampton
Gillman, Matthew W.
United States, Boston
Harvard Pilgrim Health Care Institute
Dedoussis, George V.Z.
Greece, Athens
Harokopio University of Athens
Moreno Aznar, Luis Alberto
Spain, Zaragoza
Universidad de Zaragoza
Pedersen, Oluf Borbye
Denmark, Copenhagen
Københavns Universitet
Denmark, Aarhus
Aarhus Universitet
Denmark, Gentofte
Hagedorn Research Institute
Mohlke, Karen
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Boomsma, Dorret I.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Saw, Seang Mei
Singapore, Singapore City
Duke-nus Medical School
Singapore, Singapore City
National University of Singapore
Singapore, Singapore City
Singapore Eye Research Institute
Lakka, Timo Antero
Finland, Kuopio
Itä-suomen Yliopisto
Kor̈ner, Antje
Germany, Leipzig
Universität Leipzig
Loos, Ruth J.F.
United Kingdom, Cambridge
Wellcome-mrc Institute of Metabolic Science
Ong, Ken K.L.
United Kingdom, Cambridge
Wellcome-mrc Institute of Metabolic Science
Vollenweider, Peter K.
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
van Duijn, Cornelia M.
Netherlands, Rotterdam
Erasmus Mc
Koppelman, Gerard H.
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Hattersley, Andrew T.
United Kingdom, Exeter
University of Exeter
Holloway, John W.
United Kingdom, Southampton
University of Southampton, Faculty of Medicine
Hocher, Berthold
Germany, Potsdam
Universität Potsdam
Germany, Berlin
Charité – Universitätsmedizin Berlin
Heinrich, Joachim
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Power, Chris
United Kingdom, London
University College London
Melbye, Mads
Denmark, Copenhagen
Statens Serum Institut
Guxens, M.
Spain, Barcelona
Instituto de Salud Global de Barcelona
Spain, Barcelona
Institut Municipal D'investigacio Medica
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Pennell, Craig Edward
Australia, Perth
The University of Western Australia
Bonnelykke, Klaus
Denmark, Copenhagen
Københavns Universitet
Denmark, Hellerup
Gentofte Hospital
Bisgaard, Hans
Denmark, Copenhagen
Københavns Universitet
Denmark, Hellerup
Gentofte Hospital
Eriksson, Johan Gunnar
Finland, Helsinki
Helsingin Yliopisto
Finland, Helsinki
Helsinki University Hospital
Finland, Helsinki
Folkhälsan
Finland, Vaasa
Vasa Central Sjukhus
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Widén, Elisabeth E.
Finland, Helsinki
Helsingin Yliopisto
Håkonarson, Håkon H.
United States, Philadelphia
The Children's Hospital of Philadelphia
United States, Philadelphia
University of Pennsylvania
Uitterlinden, André G.
Netherlands, Rotterdam
Erasmus Mc
Pouta, Anneli
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Finland, Oulu
Oulun Yliopisto
Lawlor, Debbie A.
United Kingdom, Bristol
University of Bristol
Smith, George D.
United Kingdom, Bristol
University of Bristol
Frayling, Tim M.
United Kingdom, Plymouth
Plymouth University, Peninsula Schools of Medicine and Dentistry
McCarthy, Mark I.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Grant, Struan F.A.
United States, Philadelphia
The Children's Hospital of Philadelphia
United States, Philadelphia
University of Pennsylvania
Jaddoe, Vincent W.V.
Netherlands, Rotterdam
Erasmus Mc
J̈arvelin, Märjo Riitta R.
United Kingdom, London
Imperial College London
Finland, Oulu
Oulun Yliopisto
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Timpson, Nicholas J.
United Kingdom, Bristol
University of Bristol
Prokopenko, Inga I.
United Kingdom, Oxford
University of Oxford
Freathy, Rachel M.
United Kingdom, Plymouth
Plymouth University, Peninsula Schools of Medicine and Dentistry
United Kingdom, Bristol
University of Bristol
Statistics
Citations: 237
Authors: 146
Affiliations: 77
Identifiers
Doi:
10.1038/ng.2477
ISSN:
15461718
Research Areas
Genetics And Genomics
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cohort Study
Study Approach
Systematic review