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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Proteomic Profiling in Patients With Peripartum Cardiomyopathy: A Biomarker Study of the ESC EORP PPCM Registry
JACC: Heart Failure, Volume 11, No. 12, Year 2023
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Description
Background: Peripartum cardiomyopathy (PPCM) remains an important cause of maternal morbidity and mortality globally. The pathophysiology remains incompletely understood, and the diagnosis is often missed or delayed. Objectives: This study explored the serum proteome profile of patients with newly diagnosed PPCM, as compared with matched healthy postpartum mothers, to unravel novel protein biomarkers that would further an understanding of the pathogenesis of PPCM and improve diagnostic precision. Methods: Study investigators performed untargeted serum proteome profiling using data-independent acquisition–based label-free quantitative liquid chromatography–tandem mass spectrometry on 84 patients with PPCM, as compared with 29 postpartum healthy controls (HCs). Significant changes in protein intensities were determined with nonpaired Student's t-tests and were further classified by using the Boruta algorithm. The proteins’ diagnostic performance was evaluated by area under the curve (AUC) and validated using the 10-fold cross-validation. Results: Patients with PPCM presented with a mean left ventricular ejection fraction of 33.5% ± 9.3% vs 57.0% ± 8.8% in HCs (P < 0.001). Study investigators identified 15 differentially up-regulated and 14 down-regulated proteins in patients with PPCM compared with HCs. Seven of these proteins were recognized as significant by the Boruta algorithm. The combination of adiponectin, quiescin sulfhydryl oxidase 1, inter-α-trypsin inhibitor heavy chain, and N-terminal pro–B-type natriuretic peptide had the best diagnostic precision (AUC: 0.90; 95% CI: 0.84-0.96) to distinguish patients with PPCM from HCs. Conclusions: Salient biologic themes related to immune response proteins, inflammation, fibrosis, angiogenesis, apoptosis, and coagulation were predominant in patients with PPCM compared with HCs. These newly identified proteins warrant further evaluation to establish their role in the pathogenesis of PPCM and potential use as diagnostic markers. © 2023 American College of Cardiology Foundation
Authors & Co-Authors
Kodogo, Vitaris
South Africa, Cape Town
University of Cape Town
Viljoen, Charle André
South Africa, Cape Town
University of Cape Town
South Africa, Cape Town
Faculty of Health Sciences
Hoevelmann, Julian
South Africa, Cape Town
University of Cape Town
Germany, Homburg
Universitätsklinikum Des Saarlandes Medizinische Fakultät Der Universität Des Saarlandes
Chakafana, Graham
South Africa, Cape Town
University of Cape Town
United States, Hampton
Hampton University
Tromp, Jasper
Singapore, Singapore City
National University Health System
Singapore, Singapore City
Duke-nus Medical School
Farhan, Hasan Ali
Unknown Affiliation
Goland, Sorel
Israel, Rehovot
Kaplan Medical Center
van der Meer, Peter
Netherlands, Groningen
Rijksuniversiteit Groningen
Karaye, Kamilu Musa
Nigeria, Kano
Bayero University
Hilfiker-Kleiner, Denise
Germany, Hannover
Hannover Medical School
Jackson, Alice M.
United Kingdom, Glasgow
University of Glasgow
Mebazaa, Alexandre
France, Paris
Inserm
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Böhm, Michael
South Africa, Cape Town
University of Cape Town
Germany, Homburg
Universitätsklinikum Des Saarlandes Medizinische Fakultät Der Universität Des Saarlandes
Pieske, Burkert Mathias
Germany, Berlin
Charité – Universitätsmedizin Berlin
Bauersachs, Johann
Germany, Hannover
Hannover Medical School
Bell, Liam
South Africa, Cape Town
Centre for Proteomic and Genomic Research
Sliwa, Karen S.
South Africa, Cape Town
University of Cape Town
South Africa, Cape Town
Faculty of Health Sciences
Statistics
Citations: 2
Authors: 17
Affiliations: 16
Identifiers
Doi:
10.1016/j.jchf.2023.07.028
ISSN:
22131779
Research Areas
Cancer
Maternal And Child Health
Study Approach
Quantitative