Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques
Proceedings of the National Academy of Sciences of the United States of America, Volume 117, No. 38, Year 2020
Notification
URL copied to clipboard!
Description
Social experience is an important predictor of disease susceptibility and survival in humans and other social mammals. Chronic social stress is thought to generate a proinflammatory state characterized by elevated antibacterial defenses and reduced investment in antiviral defense. Here we manipulated long-term social status in female rhesus macaques to show that social subordination alters the gene expression response to ex vivo bacterial and viral challenge. As predicted by current models, bacterial lipopolysaccharide polarizes the immune response such that low status corresponds to higher expression of genes in NF-κB-dependent proinflammatory pathways and lower expression of genes involved in the antiviral response and type I IFN signaling. Counter to predictions, however, low status drives more exaggerated expression of both NF-κB- and IFN-associated genes after cells are exposed to the viral mimic Gardiquimod. Status-driven gene expression patterns are linked not only to social status at the time of sampling, but also to social history (i.e., past social status), especially in unstimulated cells. However, for a subset of genes, we observed interaction effects in which females who fell in rank were more strongly affected by current social status than those who climbed the social hierarchy. Taken together, our results indicate that the effects of social status on immune cell gene expression depend on pathogen exposure, pathogen type, and social history - in support of social experience-mediated biological embedding in adulthood, even in the conventionally memoryless innate immune system. © 2020 National Academy of Sciences. All rights reserved.
Authors & Co-Authors
Sanz, Joaquín
Canada, Montreal
Chu Sainte-justine - le Centre Hospitalier Universitaire Mère-enfant
Canada, Montreal
University of Montreal
United States, Chicago
The University of Chicago
Maurizio, Paul L.
United States, Chicago
The University of Chicago
Snyder-Mackler, Noah
United States, Durham
Duke University
Simons, Noah D.
United States, Durham
Duke University
Voyles, Tawni N.
United States, Durham
Duke University
Kohn, Jordan N.
United States, Atlanta
Emory University
Michopoulos, V. J.
United States, Atlanta
Emory University
United States, Atlanta
Emory University School of Medicine
Wilson, Mark E.
United States, Atlanta
Emory University
United States, Atlanta
Emory University School of Medicine
Tung, Jenny
United States, Durham
Duke University
Barreiro, Luis B.
Canada, Montreal
Chu Sainte-justine - le Centre Hospitalier Universitaire Mère-enfant
United States, Chicago
The University of Chicago
Statistics
Citations: 23
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1073/pnas.1820846116
ISSN:
00278424
Research Areas
Genetics And Genomics
Participants Gender
Female