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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Efficacy of daily and monthly high-dose calciferol in vitamin D-deficient nulliparous and lactating women
American Journal of Clinical Nutrition, Volume 85, No. 6, Year 2007
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Description
Background: We previously found a high prevalence of vitamin D deficiency and low medication regimen compliance in Arab and East Indian women residing in the United Arab Emirates (UAE). The appropriate dosing regimen for improving vitamin D status in this population is not known. Objective: We aimed to determine the efficacy of daily and monthly supplementation with vitamin D 2, the only high-dose calciferol available in the UAE, in lactating and nulliparous women. Design: Healthy lactating (n = 90) and nulliparous (n = 88) women were randomly assigned to consume 2000 IU vitamin D2/d or 60 000 IU vitamin D2/mo for 3 mo. Serum 25-hydroxyvitamin D [25(OH)D] concentrations were measured by radioimmunoassay at baseline and every month. Results: Most women had vitamin D deficiency [ie, 25(OH)D < 50 nmol/L] at study entry. Mean ± SD 25(OH)D concentrations at 3 mo were significantly higher than baseline in both lactating (39.8 ± 12.4 and 25.2 ± 10.7 nmol/L, respectively) and nulliparous (40.4 ± 23.4 and 19.3 ± 12.2 nmol/L, respectively) women (P < 0.001 for both). In total, vitamin D supplementation was effective in achieving serum 25(OH)D concentrations of ≥50 nmol/L in 21 (30%) of 71 women at endpoint. Conclusions: Oral vitamin D2 supplementation with 2000 IU/d or 60 000 IU/mo for 3 mo was safe, and it increased serum 25(OH)D concentrations significantly; however, only a small proportion of the women studied achieved concentrations of ≥50 nmol/L. This suggests that, when sunlight exposure is limited, doses of vitamin D 2 higher than those currently studied may be needed. Monthly dosing appears to be a safe and effective alternative to daily dosing. © 2007 American Society for Nutrition.
Authors & Co-Authors
Saadi, Hussein F.
United Arab Emirates, Al Ain
United Arab Emirates University
Dawodu, Adekunle H.
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
Afandi, Bachar O.
United Arab Emirates, Al Ain
Tawam Hospital
Zayed, R.
United Arab Emirates, Al Ain
General Authority for Health Services for the Emirate of Abu Dhabi
Benedict, Sheela
United Arab Emirates, Al Ain
United Arab Emirates University
Nagelkerke, Nico J.D.
United Arab Emirates, Al Ain
United Arab Emirates University
Statistics
Citations: 118
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1093/ajcn/85.6.1565
ISSN:
00029165
Research Areas
Food Security
Health System And Policy
Study Design
Cross Sectional Study
Participants Gender
Female