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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
A persistent level of CISD2 extends healthy lifespan and delays aging in mice
Human Molecular Genetics, Volume 21, No. 18, Article dds210, Year 2012
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Description
The CISD2 gene, which is an evolutionarily conserved novel gene, encodes a transmembrane protein primarily associated with the mitochondrial outer membrane. Significantly, the CISD2 gene is located within the candidate region on chromosome 4q where a genetic component for human longevity has been mapped. Previously, we have shown that Cisd2 deficiency shortens lifespan resulting in premature aging in mice. Additionally, an age-dependent decrease in Cisd2 expression has been detected during normal aging. In this study, we demonstrate that a persistent level of Cisd2 achieved by transgenic expression in mice extends their median and maximum lifespan without any apparent deleterious side effects. Cisd2 also ameliorates age-associated degeneration of the skin, skeletal muscles and neurons. Moreover, Cisd2 protects mitochondria from age-associated damage and functional decline as well as attenuating the age-associated reduction in whole-body energy metabolism. These results suggest that Cisd2 is a fundamentally important regulator of lifespan and provide an experimental basis for exploring the candidacy of CISD2 in human longevity. © The Author 2012. Published by Oxford University Press.
Authors & Co-Authors
Wang, Chihhao
Unknown Affiliation
Chen, Liang-Kung
Taiwan, Taipei
Taipei Veterans General Hospital
Kirby, Ralph
Unknown Affiliation
Statistics
Citations: 75
Authors: 3
Affiliations: 6
Identifiers
Doi:
10.1093/hmg/dds210
ISSN:
14602083
Research Areas
Genetics And Genomics
Maternal And Child Health