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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Hepatitis B viral load and risk for liver cirrhosis and hepatocellular carcinoma in the Gambia, West Africa
Journal of Viral Hepatitis, Volume 17, No. 2, Year 2010
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Description
The main objectives of this study were to define the occurrence and levels of hepatitis B virus (HBV) DNA in asymptomatic HBV carriers, cirrhosis patients and hepatocellular carcinoma (HCC) cases from The Gambia, and to evaluate the risk for cirrhosis or HCC associated with HBV viremia. We used sensitive real-time quantitative PCR assays to measure HBV DNA in samples from a case-control study consisting of 60 asymptomatic HBV carriers, 53 cirrhotic patients and 129 HCC cases. Logistic regression was used to estimate the risks of cirrhosis and HCC associated with HBV-DNA levels and HBV e antigenemia (HBeAg) detection (a surrogate marker for viral replication). Detectable HBV viremia and HBeAg positivity were both significantly associated with cirrhosis (increasing risk by fourfold and 11-fold respectively) and with HCC (increasing risk by sixfold and threefold respectively). HBV-DNA levels were significantly higher in both HCC cases and cirrhotic patients compared to asymptomatic carriers (P < 0.01 for both). High-level HBV DNA (>10 000 copies/mL) was strongly associated with both HCC and cirrhosis (17- and 39-fold increased risk). Lower level HBV viremia (200-10 000 copies/mL) conferred a significant risk of HCC, although the association with cirrhosis was not significant. In conclusion, we find that high HBV-DNA levels are strongly associated with the serious sequelae of HBV infection, independent of HBeAg status. While risk for cirrhosis and for HCC notably increases at HBV-DNA levels ≥10 000 copies/mL, low-level viremia was also associated with significant risk for HCC. © 2009 Blackwell Publishing Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2817443/bin/jvh0017-0115-SD1.doc
Authors & Co-Authors
Mendy, Maimuna E.
Unknown Affiliation
Welzel, T.
Unknown Affiliation
Lesi, Adenike Olufunmilayo
Unknown Affiliation
Hainaut, Pierre L.
Unknown Affiliation
Hall, Andrew J.
Unknown Affiliation
Kuniholm, Mark H.
Unknown Affiliation
McConkey, Samuel J.
Unknown Affiliation
Goedert, James Jerome
Unknown Affiliation
Kaye, Steve
Unknown Affiliation
Rowland-Jones, Sarah Louise
Unknown Affiliation
Whittle, Hilton C.
Unknown Affiliation
Kirk, Gregory D.
Unknown Affiliation
Statistics
Citations: 113
Authors: 12
Affiliations: 9
Identifiers
Doi:
10.1111/j.1365-2893.2009.01168.x
ISSN:
13520504
e-ISSN:
13652893
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Case-Control Study
Study Approach
Quantitative
Study Locations
Multi-countries
Gambia