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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple Gag-specific CD8
+
T-cell epitopes
Journal of Virology, Volume 81, No. 7, Year 2007
Notification
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Description
To better understand relationships between CD8+ T-cell specificity and the immune control of human immunodeficiency virus type 1 (HIV-1), we analyzed the role of HLA-B*13, an allele associated with low viremia, in a cohort of 578 C clade-infected individuals in Durban, South Africa. Six novel B*13-restricted cytotoxic T lymphocyte epitopes were defined from analyses of 37 B*13-positive subjects, including three Gag epitopes. These B*13-restricted epitopes contribute to a broad Gag-specific CD8+ response that is associated with the control of viremia. These data are consistent with data from studies of other HLA-class I alleles associated with HIV control that have shown that the targeting of multiple Gag epitopes is associated with relative suppression of viremia. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Honeyborne, Isobella
United Kingdom, Oxford
Nuffield Department of Medicine
Prendergast, Andrew J.
United Kingdom, Oxford
Nuffield Department of Medicine
Pereyra, Florencia
United States, Boston
Massachusetts General Hospital
Leslie, Alasdair J.
United Kingdom, Oxford
Nuffield Department of Medicine
Crawford, Hayley
United Kingdom, Oxford
Nuffield Department of Medicine
Payne, Rebecca P.
United Kingdom, Oxford
Nuffield Department of Medicine
Reddy, Shabashini
South Africa, Durban
University of Kwazulu-natal
Bishop, Karen S.
South Africa, Durban
University of Kwazulu-natal
Moodley, Eshia S.
South Africa, Durban
University of Kwazulu-natal
Nair, Kriebashnie S.
South Africa, Durban
University of Kwazulu-natal
van der Stok, Mary
South Africa, Durban
University of Kwazulu-natal
McCarthy, Noel Denis
United Kingdom, Oxford
Nuffield Department of Medicine
Rousseau, Christine M.
United States, Seattle
University of Washington School of Medicine
Addo, Marylyn Martina
United States, Boston
Massachusetts General Hospital
Mullins, James I.
United States, Seattle
University of Washington School of Medicine
Brander, Christian
United States, Boston
Massachusetts General Hospital
Kiepiela, Photini
South Africa, Durban
University of Kwazulu-natal
Walker, Bruce D.
United States, Boston
Massachusetts General Hospital
Goulder, Philip Jeremy Renshaw
United Kingdom, Oxford
Nuffield Department of Medicine
United States, Boston
Massachusetts General Hospital
South Africa, Durban
University of Kwazulu-natal
Statistics
Citations: 165
Authors: 19
Affiliations: 4
Identifiers
Doi:
10.1128/JVI.02689-06
ISSN:
0022538X
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cohort Study
Study Locations
South Africa