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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Effects of co-administration of artesunate and amodiaquine on some cardiovascular disease indices in rats
Food and Chemical Toxicology, Volume 49, No. 1, Year 2011
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Description
The effects of co-administration of artesunate and amodiaquine on some cardiovascular disease indices were investigated in albino rats (Rattus novergicus). The experimental animals were randomly divided into four groups: those administered distilled water (control), those administered artesunate (2. mg/kg body weight), those administered amodiaquine (6.12. mg/kg body weight) and those co-administered artesunate (2. mg/kg body weight) and amodiaquine (6.12. mg/kg body weight). The drugs were orally administered twice daily for three days after which the serum lipid profile, heart MDA content and heart ALP and ACP activities were determined. Artesunate significantly reduced (P<. 0.05) total cholesterol and HDL-cholesterol concentrations in the serum with no significant effects (P>. 0.05) on other parameters compared to controls. Amodiaquine, on the other hand, significantly reduced (P<. 0.05) serum total cholesterol concentration while it significantly increased (P<. 0.05) serum LDL-cholesterol and heart ACP activity compared to controls. Co-administration of artesunate and amodiaquine significantly reduced (P<. 0.05) total cholesterol and HDL-cholesterol concentrations in the serum while significantly increasing (P<. 0.05) serum LDL-cholesterol concentration, atherogenic index (LDL-C/HDL-C) and ACP activity in the heart compared to controls. The results obtained suggest that co-administration of artesunate and amodiaquine to patients with coronary heart disease should be with caution. © 2010 Elsevier Ltd.
Authors & Co-Authors
Adebayo, Joseph Oluwatope
Nigeria, Ilorin
University of Ilorin
Igunnu, Adedoyin
Nigeria, Ilorin
University of Ilorin
Arise, Rotimi Olusanya
Nigeria, Ilorin
University of Ilorin
Malomo, Sylvia O.
Nigeria, Ilorin
University of Ilorin
Statistics
Citations: 21
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1016/j.fct.2010.09.022
ISSN:
02786915
Research Areas
Environmental
Noncommunicable Diseases