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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Induction of labor: A comparative study of intravaginal misoprostol and dinoprostone
Taiwanese Journal of Obstetrics and Gynecology, Volume 49, No. 2, Year 2010
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Description
Objective: To compare the efficacy and safety of intravaginal misoprostol and dinoprostone for elective induction of labor in nulliparous women with an unfavorable cervix. Materials and Methods: A quasi-experimental study was conducted in Bahawal Victoria Hospital, Bahawalpur, Pakistan, from July 1, 2005 to August 31, 2006. A total of 120 primigravid women with gestational ages of > 40 weeks to < 42 weeks were divided into two groups. Group A (n = 60) was given 50 μg of misoprostol and Group B (n = 60) was given 3 mg of dinoprostone every 6 hours, for a maximum of three doses. Results: The induction to onset of significant uterine contractions and delivery intervals were lower in Group A than in Group B (6.1 vs. 7.2 hours; p = 0.16; and 8.2 vs. 11.0 hours; p = 0.007, respectively). Group A had a lower cesarean section rate than Group B (7% vs. 30%; p = 0.003), but a higher rate of uterine hyperstimulation (10% vs. 3%; p = 0.16), tachysystole (17% vs. 3%; p = 0.02), and neonatal admissions to the intensive care unit within 24 hours of delivery (4 vs. 3; p = 0.71) and after 24 hours (2 vs. 1; p = 0.56) than Group B. Conclusion: Vaginal misoprostol is more effective than dinoprostone for the elective induction of labor beyond 40 weeks of gestation, but is associated with more uterine hyperstimulation, tachysystole, and neonatal intensive care unit admissions. © 2010 Taiwan Association of Obstetrics and Gynecology.
Authors & Co-Authors
Ayaz, Aqueela
Saudi Arabia, Makkah
Hera General Hospital
Shaukat, Saima
Pakistan, Multan
Combined Military Hospital, Multan
Farooq, Mian Usman
Pakistan, Karbala
Bahawal Victoria Hospital
Mehmood, Khalid
Saudi Arabia, Makkah
Al Noor Specialist Hospital
Ahmad, Iftikhar A.
Pakistan, Karbala
Bahawal Victoria Hospital
Bahoo, Muhammad Luqman Ali
Saudi Arabia, Makkah
Hera General Hospital
Statistics
Citations: 11
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1016/S1028-4559(10)60032-0
ISSN:
10284559
e-ISSN:
10284559
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Quasi Experimental Study
Participants Gender
Female