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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Congenital malignant melanoma of the eye
Cancer, Volume 67, No. 10, Year 1991
Notification
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Description
Twenty‐three cases of congenital malignant melanoma have previously been reported. Here the authors report the first case of a congenital malignant melanoma arising in the eye. A newborn girl had a large pigmented ocular tumor, hepatomegaly, and multiple pigmented skin and choroidal lesions. The histopathologic diagnosis was of a malignant melanoma with hepatic metastases. The skin and choroidal lesions were considered to be congenital melanocytic nevi. The most plausible pathogenetic link between these two conditions was that the malignancy had arisen as a second‐hit mutation within a choroidal congenital melanocytic nevus. Despite widespread metastases the baby, treated by surgery and chemotherapy, survives in good health, aged 2 years, 10 months. Copyright © 1991 American Cancer Society
Authors & Co-Authors
Broadway, David Charles
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Taylor, David Samuel Irving
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Lang, S.
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Harper, John I.
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Madanat, Faris F.
Jordan, Amman
The University of Jordan
Pritchard, Jonathan
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Tarawneh, Musleh S.
Jordan, Amman
The University of Jordan
Statistics
Citations: 44
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1002/1097-0142(19910515)67:10<2642::AID-CNCR2820671040>3.0.CO;2-0
ISSN:
0008543X
e-ISSN:
10970142
Research Areas
Cancer
Health System And Policy
Maternal And Child Health
Participants Gender
Female