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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
An alternative approach to estimate age-related mortality of kidney transplant recipients compared to the general population: Results in favor of old-to-old transplantations
Transplant International, Volume 27, No. 2, Year 2014
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Description
Compared to dialysis, kidney transplantation appears to be the best treatment for chronic kidney failure, even for older aged patients. Nevertheless, the individual benefit of transplanting elderly patients has to be balanced against the corresponding increase in the number of patients awaiting grafts. We analyzed the excess mortality related to kidney transplant recipients by taking into account the expected mortality of the general population (additive regression model for relative survival). We applied this method to a cohort of patients who received a first deceased-donor kidney transplant between 1998 and 2009 in France (DIVAT, n = 3641). Overall 10-year mortality was 13%. As expected, recipient age was the main risk factor associated with overall mortality. In contrast, recipient age was no longer significantly associated with the excess of mortality related to kidney transplant status by subtracting the expected mortality of the general population. Delayed graft function (DGF), pretransplantation immunization, and past history of diabetes appeared as the main risk factors of this higher mortality rate. Our results constitute a strong argument in favor of kidney transplantation, regardless of the patient's age. Preventing DGF may be more effective for decreasing the risk of death specifically attributable to the disease. © 2013 Steunstichting ESOT. Published by John Wiley & Sons Ltd.
Authors & Co-Authors
Foucher, Yohann
France, Nantes
Biostatistique, Pharmacoépidémiologie et Mesures Subjectives en Santé
France, Paris
Inserm
Akl, Ahmed Ibrahim
France, Paris
Inserm
Egypt, Mansoura
Mansoura University, Urology and Nephrology Center
Rousseau, Vanessa
France, Montpellier
Université de Montpellier
Trébern-Launay, Katy
France, Nantes
Biostatistique, Pharmacoépidémiologie et Mesures Subjectives en Santé
France, Paris
Inserm
Lorent, Marine
France, Nantes
Biostatistique, Pharmacoépidémiologie et Mesures Subjectives en Santé
France, Paris
Inserm
Kessler, Michèle F.
France, Nancy
Chu de Nancy
Ladrière, Marc
France, Nancy
Chu de Nancy
Legendre, Christophe M.
France, Paris
Université Paris Cité
Kreis, Henri A.
France, Paris
Université Paris Cité
Rostaing, Lionel P.E.
France, Toulouse
Université Toulouse Iii - Paul Sabatier
Kamar, Nassim
France, Toulouse
Université Toulouse Iii - Paul Sabatier
Mourad, Georges J.
France, Montpellier
Centre Hospitalier Universitaire de Montpellier
Garrigue, Valérie
France, Montpellier
Centre Hospitalier Universitaire de Montpellier
Morélon, Emmanuel
France, Lyon
Université de Lyon
Buron, Fanny
France, Lyon
Université de Lyon
Daurès, Jean Pierre
France, Montpellier
Université de Montpellier
Soulillou, Jean Paul
France, Paris
Inserm
Giral, Magali
France, Paris
Inserm
France, Nantes
Chu de Nantes
Statistics
Citations: 18
Authors: 18
Affiliations: 10
Identifiers
Doi:
10.1111/tri.12241
ISSN:
09340874
e-ISSN:
14322277
Research Areas
Health System And Policy
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study