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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
A molecular epidemiological and genetic diversity study of tuberculosis in Ibadan, Nnewi and Abuja, Nigeria
PLoS ONE, Volume 7, No. 6, Article e38409, Year 2012
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Description
Background: Nigeria has the tenth highest burden of tuberculosis (TB) among the 22 TB high-burden countries in the world. This study describes the biodiversity and epidemiology of drug-susceptible and drug-resistant TB in Ibadan, Nnewi and Abuja, using 409 DNAs extracted from culture positive TB isolates. Methodology/Principal Findings: DNAs extracted from clinical isolates of Mycobacterium tuberculosis complex were studied by spoligotyping and 24 VNTR typing. The Cameroon clade (CAM) was predominant followed by the M. africanum (West African 1) and T (mainly T2) clades. By using a smooth definition of clusters, 32 likely epi-linked clusters related to the Cameroon genotype family and 15 likely epi-linked clusters related to other "modern" genotypes were detected. Eight clusters concerned M. africanum West African 1. The recent transmission rate of TB was 38%. This large study shows that the recent transmission of TB in Nigeria is high, without major regional differences, with MDR-TB clusters. Improvement in the TB control programme is imperative to address the TB control problem in Nigeria. © 2012 Lawson et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3377642/bin/pone.0038409.s001.xlsx
Authors & Co-Authors
Lawson, L. L.O.
Nigeria, Abuja
Zankli Medical Centre
Zhang, Jian
France, Paris
Cnrs Centre National de la Recherche Scientifique
Gomgnimbou, Michel Kiréopori
France, Paris
Cnrs Centre National de la Recherche Scientifique
Abdurrahman, Saddiq Tsimiri
Nigeria, Abuja
National Tuberculosis and Leprosy Control Programme
Le Moullec, Stéphanie
France, Paris
Cnrs Centre National de la Recherche Scientifique
Mohamed, Fatima
France, Paris
Cnrs Centre National de la Recherche Scientifique
Uzoewulu, Gertrude N.
Nigeria, Nnewi
Nnamdi Azikiwe Teaching Hospital
Sogaolu, Olumide M.
Nigeria, Ibadan
University College Hospital, Ibadan
Goh, Khye Seng
France
Tuberculosis Laboratory Consultant
Emenyonu, Nnamdi E.
Nigeria, Abuja
Zankli Medical Centre
Refrégier, Guislaine
France, Paris
Cnrs Centre National de la Recherche Scientifique
Eduardo Cuevas, Luis Eduardo
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Sola, Christophe Noel
France, Paris
Cnrs Centre National de la Recherche Scientifique
Statistics
Citations: 49
Authors: 13
Affiliations: 7
Identifiers
Doi:
10.1371/journal.pone.0038409
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Cameroon
Nigeria