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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Accumulation of HIV drug resistance mutations in patients failing first-line antiretroviral treatment in South Africa
AIDS Research and Human Retroviruses, Volume 28, No. 2, Year 2012
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Description
Patients failing antiretroviral treatment for extended periods of time are at risk of accumulating HIV drug resistance mutations (DRMs), which negatively influences second-line treatment. This retrospective study assessed the rate of DRM accumulation among South African patients with continued virological failure. Serial genotypic resistance testing was performed and DRMs were scored according to the 2009 IAS-USA list. Among 43 patients, 38 (88.4%) harbored ≥1 DRM. The median time between two sequential resistance tests was 5 months (IQR: 3-10). Thymidine analogue mutations accumulated at a rate of 0.07 mutation per month of drug exposure, which is faster than previously reported. Routine virological monitoring should be implemented in resource-limited settings to preserve susceptibility to second-line regimens. © Copyright 2012, Mary Ann Liebert, Inc.
Authors & Co-Authors
Sigaloff, Kim Catherina Eve
Netherlands, Amsterdam
Pharmaccess Foundation
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Ramatsebe, Tina
South Africa, Johannesburg
University of the Witwatersrand
Viana, Raquel V.
South Africa, Johannesburg
University of the Witwatersrand
Rinke de Wit, Tobias Floris
Netherlands, Amsterdam
Pharmaccess Foundation
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Wallis, Carole Lorraine
South Africa, Johannesburg
University of the Witwatersrand
Stevens, Wendy Susan
South Africa, Johannesburg
University of the Witwatersrand
Statistics
Citations: 79
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1089/aid.2011.0136
ISSN:
08892229
e-ISSN:
19318405
Research Areas
Cancer
Infectious Diseases
Study Design
Cohort Study
Study Locations
South Africa