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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Identification of amino acid substitutions associated with neutralization phenotype in the human immunodeficiency virus type-1 subtype C gp120
Virology, Volume 409, No. 2, Year 2011
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Description
Neutralizing antibodies (Nabs) are thought to play an important role in prevention and control of HIV-1 infection and should be targeted by an AIDS vaccine. It is critical to understand how HIV-1 induces Nabs by analyzing viral sequences in both tested viruses and sera. Neutralization susceptibility to antibodies in autologous and heterologous plasma was determined for multiple Envs (3-6) from each of 15 subtype-C-infected individuals. Heterologous neutralization was divided into two distinct groups: plasma with strong, cross-reactive neutralization (n = 9) and plasma with weak neutralization (n = 6). Plasma with cross-reactive heterologous Nabs also more potently neutralized contemporaneous autologous viruses. Analysis of Env sequences in plasma from both groups revealed a three-amino-acid substitution pattern in the V4 region that was associated with greater neutralization potency and breadth. Identification of such potential neutralization signatures may have important implications for the development of HIV-1 vaccines capable of inducing Nabs to subtype C HIV-1. © 2010 Elsevier Inc.
Authors & Co-Authors
Kirchherr, Jennifer L.
United States, Durham
Duke University Medical Center
Hamilton, Jennifer
United States, Durham
Duke University Medical Center
Lu, Xiaozhi
United States, Durham
Duke University Medical Center
Gnanakaran, Sandrasegaram
United States, Los Alamos
Los Alamos National Laboratory
Muldoon, Mark
United Kingdom, Manchester
The University of Manchester
Daniels, Marcus G.
United States, Los Alamos
Los Alamos National Laboratory
Kasongo, Webster
Zambia, Ndola
Tropical Diseases Research Centre Ndola
Chalwe, Victor
Zambia, Ndola
Tropical Diseases Research Centre Ndola
Mulenga, Chanda
Zambia, Ndola
Tropical Diseases Research Centre Ndola
Mwananyanda, Lawrence M.
Zambia, Ndola
Tropical Diseases Research Centre Ndola
Musonda, Rosemary Mubanga
Zambia, Ndola
Tropical Diseases Research Centre Ndola
Yuan, Xing
United States, Durham
Duke University Medical Center
Montefiori, David Charles
United States, Durham
Duke University Medical Center
Korber, Bette T.
United States, Los Alamos
Los Alamos National Laboratory
United States, Santa fe
Santa fe Institute
Haynes, Barton F.
United States, Durham
Duke University Medical Center
Gao, Feng
United States, Durham
Duke University Medical Center
Statistics
Citations: 16
Authors: 16
Affiliations: 5
Identifiers
Doi:
10.1016/j.virol.2010.09.031
ISSN:
00426822
e-ISSN:
10960341
Research Areas
Infectious Diseases