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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting
Proceedings of the National Academy of Sciences of the United States of America, Volume 104, No. 44, Year 2007
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Description
Malaria has been a major selective force on the human population, and several erythrocyte polymorphisms have evolved that confer resistance to severe malaria. Plasmodium falciparum rosetting, a parasite virulence phenotype associated with severe malaria, is reduced in blood group O erythrocytes compared with groups A, B, and AB, but the contribution of the ABO blood group system to protection against severe malaria has received little attention. We hypothesized that blood group O may confer resistance to severe falciparum malaria through the mechanism of reduced rosetting. In a matched case-control study of 567 Malian children, we found that group O was present in only 21% of severe malaria cases compared with 44-45% of uncomplicated malaria controls and healthy controls. Group O was associated with a 66% reduction in the odds of developing severe malaria compared with the non-O blood groups (odds ratio 0.34, 95% confidence interval 0.19-0.61, P < 0.0005, severe cases versus uncomplicated malaria controls). In the same sample set, P. falciparum rosetting was reduced in parasite isolates from group O children compared with isolates from the non-O blood groups (P = 0.003, Kruskal-Wallis test). Statistical analysis indicated a significant interaction between host ABO blood group and parasite rosette frequency that supports the hypothesis that the protective effect of group O operates through the mechanism of reduced P. falciparum rosetting. This work provides insights into malaria pathogenesis and suggests that the selective pressure imposed by malaria may contribute to the variable global distribution of ABO blood groups in the human population. © 2007 by The National Academy of Sciences of the USA.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2077280/bin/pnas_0705390104_index.html
Authors & Co-Authors
Rowe, Jane Alexandra
United Kingdom, Edinburgh
The University of Edinburgh
Handel, Ian Graham
United Kingdom, Edinburgh
The University of Edinburgh
Thera, Mahamadou Ali
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Deans, Anne Marie
United Kingdom, Edinburgh
The University of Edinburgh
Lyke, Kirsten E.
United States, Baltimore
University of Maryland, Baltimore Umb
Koné, Abdoulaye Kassoum
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Diallo, Dapa Aly
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Raza, Ahmed J.
United Kingdom, Edinburgh
The University of Edinburgh
Kai, Oscar K.
United States, Philadelphia
Glaxosmithkline, Usa
Marsh, Kevin
United States, Philadelphia
Glaxosmithkline, Usa
Plowe, Christopher Vv
United States, Baltimore
University of Maryland, Baltimore Umb
Doumbo, Ogobara K.
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Moulds, Joann M.
United States, Shreveport
Lifeshare Blood Centers
Statistics
Citations: 353
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1073/pnas.0705390104
ISSN:
00278424
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Case-Control Study
Study Approach
Quantitative