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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Molecular subtype analysis determines the association of advanced breast cancer in Egypt with favorable biology
BMC Women's Health, Volume 11, Article 44, Year 2011
Notification
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Description
Background: Prognostic markers and molecular breast cancer subtypes reflect underlying biological tumor behavior and are important for patient management. Compared to Western countries, women in North Africa are less likely to be prognosticated and treated based on well-characterized markers such as the estrogen receptor (ER), progesterone receptor (PR) and Her2. We conducted this study to determine the prevalence of breast cancer molecular subtypes in the North African country of Egypt as a measure of underlying biological characteristics driving tumor manifestations.Methods: To determine molecular subtypes we characterized over 200 tumor specimens obtained from Egypt by performing ER, PR, Her2, CK5/6, EGFR and Ki67 immunohistochemistry.Results: Our study demonstrated that the Luminal A subtype, associated with favorable prognosis, was found in nearly 45% of cases examined. However, the basal-like subtype, associated with poor prognosis, was found in 11% of cases. These findings are in sharp contrast to other parts of Africa in which the basal-like subtype is over-represented.Conclusions: Egyptians appear to have favorable underlying biology, albeit having advanced disease at diagnosis. These data suggest that Egyptians would largely profit from early detection of their disease. Intervention at the public health level, including education on the benefits of early detection is necessary and would likely have tremendous impact on breast cancer outcome in Egypt. © 2011 Salhia et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Salhia, Bodour
United States, Phoenix
Translational Genomics Research Institute
Tapia, Coya
Switzerland, Basel
Universitätsspital Basel Institute of Pathology
Switzerland, Bern
University of Bern
Ishak, Elia Anis
Egypt, Cairo
Faculty of Medicine
Gaber, Salwa
Egypt, Minya
Faculty of Medicine
Berghuis, Bree
United States, Grand Rapids
Van Andel Research Institute
Hussain, Khateeb H.
United States, Phoenix
Translational Genomics Research Institute
DuQuette, Rachelle A.
United States, Phoenix
Translational Genomics Research Institute
Resau, James
United States, Grand Rapids
Van Andel Research Institute
Carpten, John David
United States, Phoenix
Translational Genomics Research Institute
Statistics
Citations: 73
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1186/1472-6874-11-44
e-ISSN:
14726874
Research Areas
Cancer
Health System And Policy
Study Design
Randomised Control Trial
Cross Sectional Study
Study Locations
Multi-countries
Egypt
Participants Gender
Female