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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Toxic and mutagenic properties of extracts from Tunisian traditional medicinal plants investigated by the neutral red uptake, VITOTOX and alkaline comet assays
South African Journal of Botany, Volume 77, No. 3, Year 2011
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Description
We investigated the genotoxic properties of a number of extracts from Tunisian traditional medicinal plants with the bacterial VITOTOX test in Salmonella typhimurium and the alkaline comet assay in human C3A cells. Ethyl acetate and methanol extracts from Marrubium alysson L. and Retama raetam (Forsk.) Webb and methanol extracts from Peganum harmala L. were investigated. Toxicity was furthermore studied with the neutral red uptake test that served for dose-finding. All extracts showed antigenotoxic properties against 4-nitroquinoline-oxide (4-NQO) and benzo(α)pyrene in the VITOTOX test, except the methanol extracts from R. raetam where antigenotoxicity was not found against the mutagen 4-NQO (in the absence of S9). The ethyl acetate extract from R. raetam was found mutagenic with the VITOTOX test in the absence of S9, whereas both ethylacetate and methanol extracts of M. alysson L. induced DNA damage according to the alkaline comet assay in C3A cells. © 2011 SAAB.
Authors & Co-Authors
Edziri, H.
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Mastouri, Maha
Tunisia, Monastir
Laboratoire de Microbiologie C h u Fattouma Bouguiba
Aouni, Mahjoub
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Anthonissen, Roel
Belgium, Brussels
Scientific Institute of Public Health, Brussels
Mertens, Birgit
Belgium, Brussels
Scientific Institute of Public Health, Brussels
Cammaerts, S.
Belgium, Brussels
Scientific Institute of Public Health, Brussels
Belgium, Antwerpen
Universiteit Antwerpen
Gevaert, L.
Unknown Affiliation
Verschaeve, Luc
Belgium, Brussels
Scientific Institute of Public Health, Brussels
Belgium, Antwerpen
Universiteit Antwerpen
Statistics
Citations: 18
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1016/j.sajb.2011.03.007
ISSN:
02546299
Research Areas
Environmental
Genetics And Genomics
Infectious Diseases