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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Flow-injection chemiluminometric determination of some phenothiazines in dosage forms and biological fluids
Analytica Chimica Acta, Volume 358, No. 3, Year 1998
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Description
A rapid and sensitive flow-injection chemiluminometric method is described for the determination of three phenothiazine derivatives, namely, fluphenazine hydrochloride, levomepromazine hydrochloride and trimeprazine tartrate. The method is based on the chemiluminescence (CL) induced by the oxidation of drugs with cerium(IV) in an acidic medium. The CL intensity is greatly enhanced when rhodamine B is used as a sensitizer in the case of levomepromazine hydrochloride and trimeprazine tartrate. The proposed method allows the measurement of 0.5-90 μg ml-1 fluphenazine and 0.1-6.5 μg ml-1 levomepromazine and trimeprazine. The limits of detection (3σ) were 0.01 μg ml-1 fluphenazine hydrochloride and 0.1 μg ml-1 for the other two drugs. The method was applied successfully in determining the drugs in dosage form as well as in biological fluids, © 1998 Elsevier Science B.V.
Authors & Co-Authors
Aly, Fatma Ahmed
Saudi Arabia, Riyadh
College of Sciences
Alarfaj, Nawal Ahmad A.
Saudi Arabia, Riyadh
College of Sciences
Al-Warthan, Abdulrahman Abdullah
Saudi Arabia, Riyadh
College of Sciences
Statistics
Citations: 46
Authors: 3
Affiliations: 1
Identifiers
Doi:
10.1016/S0003-2670(97)00622-3