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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Adverse events to antiretrovirals in the Swiss HIV Cohort Study: Effect on mortality and treatment modification
Antiviral Therapy, Volume 12, No. 8, Year 2007
Notification
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Description
Background: Antiretroviral therapy (ART) decreases morbidity and mortality in HIV-infected patients but is associated with considerable adverse events (AEs). Methods: We examined the effect of AEs to ART on mortality, treatment modifications and drop-out in the Swiss HIV Cohort Study. A cross-sectional evaluation of prevalence of 13 clinical and 11 laboratory parameters was performed in 1999 in 1,078 patients on ART. AEs were defined as abnormalities probably or certainly related to ART. A score including the number and severity of AEs was defined. The subsequent progression to death, drop-out and treatment modification due to intolerance were evaluated according to the baseline AE score and characteristics of individual AEs. Results: Of the 1,078 patients, laboratory AEs were reported in 23% and clinical AEs in 45%. During a median follow up of 5.9 years, laboratory AEs were associated with higher mortality with an adjusted hazard ratio (HR) of 1.3 (95% confidence interval [CI] 1.2-1.5; P<0.001) per score point. For clinical AEs no significant association with increased mortality was found. In contrast, an increasing score for clinical AEs (HR 1.11, 95% CI 1.04-1.18; P=0.002), but not for laboratory AEs (HR 1.07, 95% CI 0.97-1.17; P=0.17), was associated with antiretroviral treatment modification. AEs were not associated with a higher drop-out rate. Conclusions: The burden of laboratory AEs to antiretroviral drugs is associated with a higher mortality. Physicians seem to change treatments to relieve clinical symptoms, while accepting laboratory AEs. Minimizing laboratory drug toxicity seems warranted and its influence on survival should be further evaluated. © 2007 International Medical Press.
Authors & Co-Authors
Keiser, Olivia
Switzerland, Bern
University of Bern
Fellay, Jacques
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Opravil, Milos
Switzerland, Zurich
Universitatsspital Zurich
Hirsch, Hans H.
Switzerland, Basel
University of Basel, Institute for Medical Microbiology
Hirschel, B. J.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Bernasconi, Enos
Switzerland, Bellinzona
Ente Ospedaliero Cantonale
Vernazza, Pietro Luigi
Switzerland, St Gallen
Kantonsspital St.gallen
Rickenbach, Martin
Switzerland, Lausanne
Swiss Hiv Cohort Study Data Center
Telenti, Amalio
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Furrer, Hansjakob Jackob
Switzerland, Bern
University of Bern
Battegay, Manuel
Unknown Affiliation
Bernasconi, Enos
Unknown Affiliation
Böni, Jürg
Unknown Affiliation
Bucher, Heiner C.
Unknown Affiliation
Bürgisser, Ph
Unknown Affiliation
Cattacin, Sandro
Unknown Affiliation
Cavassini, Matthias L.
Unknown Affiliation
Dubs, Rolf W.
Unknown Affiliation
Egger, Matthias
Unknown Affiliation
Elzi, Luigia
Unknown Affiliation
Erb, Peter
Unknown Affiliation
Fischer, Marek
Unknown Affiliation
Flepp, Markus J.
Unknown Affiliation
Fontana, Adriano
Unknown Affiliation
Francioli, Patrick B.
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Furrer, Hansjakob
Unknown Affiliation
Gorgievski, Meri
Unknown Affiliation
Günthard, Hüldrych Fritz
Unknown Affiliation
Hirschel, B.
Unknown Affiliation
Hösli, Irene Mathilde
Unknown Affiliation
Kahlert, Christian R.
Unknown Affiliation
Kaiser, Laurent K.
Unknown Affiliation
Karrer, Urs
Unknown Affiliation
Kind, Christian H.
Unknown Affiliation
Klimkait, Thomas
Unknown Affiliation
Ledergerber, Bruno
Unknown Affiliation
Martinez, Begogna
Unknown Affiliation
Müller, Nicolas J.
Unknown Affiliation
Nadal, David
Unknown Affiliation
Paccaud, Fred Michel
Unknown Affiliation
Pantaleo, Giuseppe P.
Unknown Affiliation
Perrin, Luc Henri
Unknown Affiliation
Piffaretti, Jean Claude L.
Unknown Affiliation
Rudin, Christoph
Unknown Affiliation
Schmid, Patrick
Unknown Affiliation
Schültze, Detlev
Unknown Affiliation
Schüpbach, Jörg Rg
Unknown Affiliation
Speck, Roberto F.
Unknown Affiliation
Taffé, Patrick
Unknown Affiliation
Tarr, Philip E.
Unknown Affiliation
Trkola, Alexandra
Unknown Affiliation
Vernazza, Pietro L.
Unknown Affiliation
Weber, Rainer
Unknown Affiliation
Yerly, Sabine T.B.D.
Unknown Affiliation
Statistics
Citations: 48
Authors: 54
Affiliations: 8
Identifiers
ISSN:
13596535
Research Areas
Environmental
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative