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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Decreased darunavir concentrations during once-daily co-administration with maraviroc and raltegravir: OPTIPRIM-ANRS 147 trial
Journal of Antimicrobial Chemotherapy, Volume 73, No. 4, Year 2018
Notification
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Description
Background: The OPTIPRIM-ANRS 147 trial compared intensive combination ART (darunavir/ritonavir, tenofovir disoproxil fumarate/emtricitabine, raltegravir and maraviroc) started early during primary HIV-1 infection with standard tritherapy with darunavir/ritonavir, tenofovir disoproxil fumarate and emtricitabine. From month 6 to 18, the percentage of viral load values <50 copies/mL was lower in the pentatherapy arm than in the tritherapy arm. Herewe compared antiretroviral drug concentrations between the two arms. Methods: Plasma samples were collected from 50 patients at various times after drug administration. A Bayesian approach based on published population pharmacokinetic models was used to estimate residual drug concentrations (Ctrough) and exposures (AUC) in each patient. A mixed linear regression model was then used to compare the AUC and Ctrough values of each drug used in both groups. Results: Published models adequately described our data and could be used to predict Ctrough and AUC. No significant difference in tenofovir disoproxil fumarate, emtricitabine and ritonavir parameters was found between the two arms. However, darunavir Ctrough and AUC were significantly lower in the pentatherapy arm than in the tritherapy arm (P=0.03 and P=0.04, respectively). Conclusions: Adding maraviroc and raltegravir to darunavir-based tritherapy decreased darunavir concentrations. Compliance issues, maraviroc-darunavir interaction and raltegravir-darunavir interaction were suspected and may affect the kinetics of viral decay during pentatherapy. A specific pharmacokinetic interaction study is needed to explore the interactions between darunavir and maraviroc and raltegravir. © The Author(s) 2018. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy.
Authors & Co-Authors
Pressiat, Claire
France, Paris
Université Paris Cité
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Hirt, Déborah
France, Paris
Université Paris Cité
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Tréluyer, Jean Marc
France, Paris
Université Paris Cité
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Zheng, Yi
France, Paris
Université Paris Cité
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Morlat, Philippe
France, Talence
Centre Hospitalier Universitaire de Bordeaux
Viard, Jean Paul
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Paris
Université Paris Cité
Avettand-Fenoel, Véronique
France, Paris
Université Paris Cité
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Rouzioux, Christine
France, Paris
Université Paris Cité
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Meyer, Laurence J.
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Hoën, Bruno
France, Le Kremlin-bicetre
Hopital de Bicetre
Delfraissy, Jean François
France, Paris
Hôpital Lariboisiere Ap-hp
Goujard, Cécile D.Sign©cile
France, Paris
Hôpital Lariboisiere Ap-hp
Rami, Agathe
Unknown Affiliation
Diemer, Myriam
Unknown Affiliation
Allègre, Thierry
Unknown Affiliation
Duvivier, Claudine
France, Paris
Hôpital Tenon
Consigny, Paul Henri
France, Paris
Hôpital Tenon
Pialoux, Gilles
France, Paris
Hopital Cochin Ap-hp
Slama, Laurence
France, Paris
Hopital Cochin Ap-hp
Salmon, Dominique
Unknown Affiliation
Lévy, Yvés
Unknown Affiliation
Katlama, Christine
Unknown Affiliation
Simon, Anne Laure
Unknown Affiliation
Molina, Jean Michel
Unknown Affiliation
Scemla, Anne
Unknown Affiliation
de Castro, Nathalie
Unknown Affiliation
Rachline, Anne C.
Unknown Affiliation
Rozenbaum, Willey
Unknown Affiliation
Ferret, Samuel
Unknown Affiliation
Balkan, Suna
Unknown Affiliation
Clavel, François
Unknown Affiliation
Tourdjman, Mathieu
Unknown Affiliation
de Lastours, Victoire
Unknown Affiliation
Gallien, Sébastien
Unknown Affiliation
Pavie, Juliette
Unknown Affiliation
Chennebault, Jean Marie
France, Angers
Chu Angers
Abgueguen, Pierre
France, Angers
Chu Angers
Vandenhende, Marianne
Unknown Affiliation
Receveur, Marie Catherine
Unknown Affiliation
Livrozet, Jean Michel
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Yéni, Patrick G.
France, Montpellier
Hopital Gui de Chauliac
Talbi, Emna Ghazali
France, Montpellier
Hopital Gui de Chauliac
Reynès, Jacques M.
Unknown Affiliation
Makinson, Alain
Unknown Affiliation
Raffi, François
Unknown Affiliation
Allavena, Clotilde
Unknown Affiliation
Reliquet, Véronique
Unknown Affiliation
Billaud, Éric
Unknown Affiliation
Dellamonica, Pierre
Unknown Affiliation
Vassallo, Matteo
Unknown Affiliation
Durant, Jacques M.
Unknown Affiliation
Joulié, Aline
Unknown Affiliation
Michelet, Christian
Unknown Affiliation
Arvieux, Cédric
Unknown Affiliation
Tattevin, Pierre
Unknown Affiliation
Fily, Fabien
Unknown Affiliation
Chapplain, Jean Marc
Unknown Affiliation
Bernard, Louis
Unknown Affiliation
Marchou, Bruno
Unknown Affiliation
Chauveau, Marie
Unknown Affiliation
Ajana, Faïza
Unknown Affiliation
Alcaraz, Isabelle
Unknown Affiliation
Poissy, Julien
Unknown Affiliation
Ravaux, Isabelle
Unknown Affiliation
May, Thierry
France, Rouen
Hopital Charles Nicolle
Gueit, Isabelle
Unknown Affiliation
Cotte, Laurent
Unknown Affiliation
Boibieux, André
Unknown Affiliation
Ferry, Tristan
Unknown Affiliation
Biron, François
Unknown Affiliation
Koffi, Joseph
Unknown Affiliation
Belan, Alix Greder
Unknown Affiliation
Statistics
Citations: 1
Authors: 72
Affiliations: 14
Identifiers
Doi:
10.1093/jac/dkx498
ISSN:
03057453
Research Areas
Cancer
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study