Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Kinetics of rebounding of lymphoid and myeloid cells in mouse peripheral blood, spleen and bone marrow after treatment with cyclophosphamide
Cellular Immunology, Volume 276, No. 1-2, Year 2012
Notification
URL copied to clipboard!
Description
Recently, we showed that post cyclophosphamide (CTX) microenvironment benefits the function of transferred T cells. Analysis of the kinetics of cellular recovery after CTX treatment showed that a single 4mg/mouse CTX treatment decreased the absolute number of leukocytes in the peripheral blood (PBL) at days 3-15, and in the spleen and bone marrow (BM) at days 3-6. The absolute numbers of CD11c +CD11b - and CD11c +CD11b + dendritic cells (DCs), CD11b + and Ly6G + myeloid cells, T and B cells, CD4 +CD25 + T regulatory (T reg) cells, and NK1.1 + cells also decreased. The cell numbers returned to control levels during the recovery phase. The absolute numbers of B cells remained low for 3weeks. The numbers of DCs increased in PBL and spleen at day 9 but returned to control levels at day 15. These data indicate that CTX alters the cellular microenvironment in kinetics that might be precisely targeted to benefit the host. © 2012 Elsevier Inc.
Authors & Co-Authors
Salem, Mohamed Labib
Egypt, Tanta
Faculty of Science
Al-Khami, Amir A.
Egypt, Tanta
Faculty of Science
United States, Charleston
Medical University of South Carolina
El-Nagaar, Sabry A.
Egypt, Tanta
Faculty of Science
Saudi Arabia, Sakakah
Jouf University
Zidan, Abdel-Aziz Aziz A.
United States, Miami
Sylvester Comprehensive Cancer Center
Al-Sharkawi, Ismail Moustafa
Egypt, Tanta
Faculty of Science
Saudi Arabia, Jeddah
King Abdulaziz University
Marcela Díaz-Montero, C.
United States, Miami
Sylvester Comprehensive Cancer Center
Cole, David J.
United States, Charleston
Medical University of South Carolina
Statistics
Citations: 39
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1016/j.cellimm.2012.03.010
ISSN:
00088749
e-ISSN:
10902163