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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Ezetimibe added to statin therapy after acute coronary syndromes
New England Journal of Medicine, Volume 372, No. 25, Year 2015
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Description
BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization (≥30 days after randomization), or nonfatal stroke. The median follow-up was 6 years. RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (P<0.001). The Kaplan-Meier event rate for the primary end point at 7 years was 32.7% in the simvastatin-ezetimibe group, as compared with 34.7% in the simvastatin-monotherapy group (absolute risk difference, 2.0 percentage points; hazard ratio, 0.936; 95% confidence interval, 0.89 to 0.99; P = 0.016). Rates of pre-specified muscle, gallbladder, and hepatic adverse effects and cancer were similar in the two groups. CONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit. Copyright © 2015 Massachusetts Medical Society.
Authors & Co-Authors
Cannon, Christopher Paul
United States, Boston
Brigham and Women's Hospital
Blazing, Michael A.
United States, Durham
Duke Clinical Research Institute
Giugliano, Robert P.
United States, Boston
Brigham and Women's Hospital
White, Jennifer A.
United States, Durham
Duke Clinical Research Institute
Thèroux, Pierre A.
Canada, Montreal
Institut de Cardiologie de Montreal
Darius, Harald
Unknown Affiliation
Lewis, Basil S.
Israel, Haifa
Carmel Medical Center
Ophuis, Ton Oude
Netherlands, Nijmegen
Canisius Wilhelmina Ziekenhuis
Jukema, Johan Wouter
Netherlands, Leiden
Leids Universitair Medisch Centrum
De Ferrari, Gaetano Maria
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Ruźyłło, Witold
Poland, Warsaw
Instytut Kardiologii Im. Prymasa Tysiaclecia Stefana Kardynała Wyszynskiego
Im, Kyungah
United States, Boston
Brigham and Women's Hospital
Bohula, Erin A.
United States, Boston
Brigham and Women's Hospital
Wiviott, Stephen D.
United States, Boston
Brigham and Women's Hospital
Tershakovec, Andrew M.
United States, Rahway
Merck & Co., Inc.
Braunwald, Eugene B.
United States, Boston
Brigham and Women's Hospital
Califf, Robert M.
United States, Durham
Duke Clinical Research Institute
Gurfinkel, Enrique P.
Unknown Affiliation
Aylward, Philip E.G.
Unknown Affiliation
Tonkin, Andrew Maxwell
Unknown Affiliation
Maurer, Gerald
Unknown Affiliation
van de Werf, Frans J.J.
Unknown Affiliation
Nicolau, José Carlos
Unknown Affiliation
Genest, Jacques J.G.
Unknown Affiliation
Armstrong, Paul W.
Unknown Affiliation
Corbalàn, Ramõn L.
Unknown Affiliation
Isaza, Daniel Vanegas
Unknown Affiliation
Špinar, Jindřich
Unknown Affiliation
Grande, Peer I.
Unknown Affiliation
Farnier, Michel
Unknown Affiliation
Keltai, Mátyás
Unknown Affiliation
Reddy, K. Srinath
Unknown Affiliation
White, Harvey D.
Unknown Affiliation
Pedersen, Terje R.
Unknown Affiliation
Carrageta, Manuel Oliveira
Unknown Affiliation
Duris, Tibor
Unknown Affiliation
Dalby, Anthony John
Unknown Affiliation
López-Sendón, José Luís
Unknown Affiliation
Dellborg, Mikael
Unknown Affiliation
MacH, François
Unknown Affiliation
Güneri, Sema
Unknown Affiliation
Parkhomenko, Alexander N.
Unknown Affiliation
Brady, Adrian J.B.
Unknown Affiliation
Ballantyne, Christie Mitchell
Unknown Affiliation
Kleiman, Neal S.
Unknown Affiliation
McGuire, Darren K.
Unknown Affiliation
Cartasegna, Luis Rodolfo
Unknown Affiliation
Reges, Paula P.S.
Unknown Affiliation
Azize, Guillermo Moisés
Unknown Affiliation
Duronto, Ernesto A.
Unknown Affiliation
Carlevaro, Oscar
Unknown Affiliation
Hominal, Miguel Angel
Unknown Affiliation
Mauro, Daniel O.
Unknown Affiliation
Macín, Stella Maris
Unknown Affiliation
Nani, Sebastián
Unknown Affiliation
Fernández, Huberth
Unknown Affiliation
Bono, Julio Oscar Emilio
Unknown Affiliation
Cusimano, Sandra
Unknown Affiliation
Schygiel, Pablo Omar
Unknown Affiliation
Chew, Derek P.B.
Unknown Affiliation
Shaw, Jonathan E.
Unknown Affiliation
Cross, David B.
Unknown Affiliation
Horowitz, John D.
Unknown Affiliation
Steinwender, Clemens
Unknown Affiliation
Brussee, Helmut
Unknown Affiliation
Zweiker, Robert
Unknown Affiliation
Lang, Irene Marthe
Unknown Affiliation
Drexel, Heinz
Unknown Affiliation
Hoppe, Uta Charlotte
Unknown Affiliation
Pichler, Maximilian
Unknown Affiliation
Huber, Kurt
Unknown Affiliation
Weidinger, Franz F.
Unknown Affiliation
Metzler, Bernhard
Unknown Affiliation
Auer, Johann W.
Unknown Affiliation
Podczeck-Schweighofer, Andrea
Unknown Affiliation
Sinnaeve, Peter R.
Unknown Affiliation
Heyse, Alex M.
Unknown Affiliation
Lancellotti, Patrizio
Unknown Affiliation
Taeymans, Yves M.
Unknown Affiliation
Dujardin, Karl
Unknown Affiliation
van de Borne, Philippe J.H.
Unknown Affiliation
Saraiva, José Francisco Kerr
Unknown Affiliation
Manenti, Euler Roberto Fernandes
Unknown Affiliation
Maia, Lília Nigro
Unknown Affiliation
Kormann, Adrian Paulo Morales
Unknown Affiliation
Dutra, Óscar Pereira
Unknown Affiliation
Zucchetti, Claudio
Unknown Affiliation
Marin-Neto, José Antonio
Unknown Affiliation
Abrantes, José Antonio M.
Unknown Affiliation
Piegas, Leopoldo Soares
Unknown Affiliation
Teixeira, Marcelo Silveira
Unknown Affiliation
Précoma, Dalton Bertolim
Unknown Affiliation
Warnica, James Wayne
Unknown Affiliation
Della-Siega, Anthony J.
Unknown Affiliation
Bata, Iqbal R.
Unknown Affiliation
Gosselin, Gilbert
Unknown Affiliation
Roberts, Paul Richard
Unknown Affiliation
Ma, Patrick T.S.
Unknown Affiliation
Lönn, Eva Marie
Unknown Affiliation
McPherson, Charles E.
Unknown Affiliation
Kouz, Simon M.
Unknown Affiliation
Lamy, Andre L.
Unknown Affiliation
Gupta, Milan K.
Unknown Affiliation
Dela Cruz, Charles S.
Unknown Affiliation
Gagné, Claudé E.
Unknown Affiliation
Bergeron, Jean
Unknown Affiliation
Clarke, Aileen E.
Unknown Affiliation
Rodríguez, Manuel A.
Unknown Affiliation
Ramos, Grazielle Viana
Unknown Affiliation
García, Mario Jorge
Unknown Affiliation
Sánchez, Gregorio T.
Unknown Affiliation
de Salazar, Dora Inés Molina
Unknown Affiliation
Ruiz-Morales, Alvaro J.
Unknown Affiliation
Jaramillo, Mónica Lopez
Unknown Affiliation
Mendoza, Floreliz H.
Unknown Affiliation
Martinez, Solange
Unknown Affiliation
Castro, Rita C.
Unknown Affiliation
Hlinomaz, Ota
Unknown Affiliation
Poloczek, Martin
Unknown Affiliation
Mayer, Otto
Unknown Affiliation
Souĉek, Miroslav
Unknown Affiliation
Branný, Marián
Unknown Affiliation
Mot'ovská, Zuzana
Unknown Affiliation
Roháč, Filip
Unknown Affiliation
Solar, Miroslav
Unknown Affiliation
Hradec, Jaromír
Unknown Affiliation
Piťha, Jan
Unknown Affiliation
Linhart, Aleš
Unknown Affiliation
Clemmensen, Peter Michael
Unknown Affiliation
Beck-Jensen, Jens Erik
Unknown Affiliation
Klausen, Ib Christian
Unknown Affiliation
Peñaherrera, Ernesto
Unknown Affiliation
Duarte, Yan Carlos
Unknown Affiliation
Laanmets, Peep
Unknown Affiliation
Voutilainen, Sari
Unknown Affiliation
Laukkanen, Jari Antero
Unknown Affiliation
Hiltunen, Pamela V.C.
Unknown Affiliation
Kosonen, Petteri
Unknown Affiliation
Airaksinen, Juhani K.E.
Unknown Affiliation
Juonala, Markus T.
Unknown Affiliation
Lehto, Seppo
Unknown Affiliation
Schiele, François
Unknown Affiliation
Bassand, Jean Pierre L.
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Galinier, Michel C.
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Elbaz, Meyer
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Puel, Jacques P.
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Carrié, Didier
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Jaboureck, Olivier
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Dujardin, Jean Jacques
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Mansourati, Jacques
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Jourdain, Patrick
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Dourmap-Collas, Caroline
Unknown Affiliation
Dubois-Randé, Jean Luc
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Delahaye, Franc¸ois
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Ovize, Michel
Unknown Affiliation
Bonnet, Jean Louis
Unknown Affiliation
Belle, Loïc
Unknown Affiliation
Ohlmann, Patrick
Unknown Affiliation
Cöttin, Yves
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Ghostine, Saïd
Unknown Affiliation
Poulard, Jean Ernest
Unknown Affiliation
Davy, Jean Marc
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Furber, Alain P.
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Prunier, Fabrice
Unknown Affiliation
Münzel, Tomas F.
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Duengen, Hans Dirk
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Gross, Myron D.
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Kadel, Christoph
Unknown Affiliation
Steiner, Stephan
Unknown Affiliation
Kreuzer, Jörg G.
Unknown Affiliation
Zeiher, Andreas Michael
Unknown Affiliation
Baldus, Stephan Ernst
Unknown Affiliation
Meinhardt, Gerold
Unknown Affiliation
Nienaber, Christoph Anton
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Lapp, Harald
Unknown Affiliation
Zeymer, Uwe
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Reppel, Michael
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Schunkert, Heribert
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Weil, Joachim
Unknown Affiliation
Olbrich, Hans Georg
Unknown Affiliation
Skowasch, Dirk
Unknown Affiliation
Osterhues, Hans Heinrich
Unknown Affiliation
Klauß, Volker V.
Unknown Affiliation
Hauptmann, Karl Eugen
Unknown Affiliation
Schulze, Matthias Bernd
Unknown Affiliation
Felix, Stephan Burkhard
Unknown Affiliation
Gulba, Dietrich Christoph L.
Unknown Affiliation
Werner, Gerald S.
Unknown Affiliation
Halbach, Marcel D.
Unknown Affiliation
Laufs, Ulrich
Unknown Affiliation
Vom Dahl, Juergen V.
Unknown Affiliation
Haude, Michael
Unknown Affiliation
Birkemeyer, Ralf
Unknown Affiliation
Yu, Canqing
Unknown Affiliation
Merkely, Béla D.Signla
Unknown Affiliation
Herczeg, Béla
Unknown Affiliation
Édes, István Ferenc
Unknown Affiliation
Sereg, Mátyás
Unknown Affiliation
Manjunath, Chollenahally Nanjappa
Unknown Affiliation
Kapoor, Anil K.
Unknown Affiliation
Khan, Safi U.
Unknown Affiliation
Chopra, Vijay Kumar
Unknown Affiliation
Kaul, Upendera A.
Unknown Affiliation
Mullasari, Ajit Sankardas
Unknown Affiliation
Subban, Vijayakumar
Unknown Affiliation
Dani, Sameer Indravadan
Unknown Affiliation
Chandra, Praveen Kumar
Unknown Affiliation
Shafiq, Nusrat M.
Unknown Affiliation
Kasliwal, Ravi Ratan
Unknown Affiliation
Bansal, Manish
Unknown Affiliation
Eldar, Michael
Unknown Affiliation
Shechter, Michael
Unknown Affiliation
Hamoud, Samar
Unknown Affiliation
Leibowitz, David W.
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Zimlíchman, Reuven R.
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Halkin, Amir
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Halabi, Susan
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Caspi, Abraham
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Gavish, Dov
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Hussein, Osamah A.
Unknown Affiliation
Henkin, Yaakov
Unknown Affiliation
Zeltser, David W.
Unknown Affiliation
Elis, Avishay
Unknown Affiliation
Grossman, Ehud
Unknown Affiliation
Mennuni, Marco
Unknown Affiliation
Paloscia, Leonardo
Unknown Affiliation
Oltrona-Visconti, Luigi
Unknown Affiliation
Senni, Michele
Unknown Affiliation
Gavazzi, Antonello
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De Caterina, Raffaele
Unknown Affiliation
Novo, Salvatore
Unknown Affiliation
Perrone-Filardi, P.
Unknown Affiliation
Maresta, Aleardo
Unknown Affiliation
Golino, Paolo
Unknown Affiliation
Gensini, Gianfranco
Unknown Affiliation
Lombardi, Antonio
Unknown Affiliation
Marenzi, Giancarlo
Unknown Affiliation
Terrosu, Pierfranco
Unknown Affiliation
Ragni, Margaret V.
Unknown Affiliation
Rapezzi, Claudio
Unknown Affiliation
Marra, Sebastiano
Unknown Affiliation
Usmiani, Tullio
Unknown Affiliation
Fedele, Francesco
Unknown Affiliation
De Maria, Elia
Unknown Affiliation
Gabrielli, Domenico
Unknown Affiliation
Di Biase, Matteo
Unknown Affiliation
Fattore, Luciano
Unknown Affiliation
Cavallini, Claudio
Unknown Affiliation
Tamburino, Corrado
Unknown Affiliation
Russo, Vincenzo C.
Unknown Affiliation
Volpe, Massimo
Unknown Affiliation
Modena, Maria Grazia
Unknown Affiliation
Cianflone, Domenico
Unknown Affiliation
Cristell, Nicole A.
Unknown Affiliation
Indolfi, Ciro
Unknown Affiliation
Guerra, Federico
Unknown Affiliation
Iliceto, Sabino
Unknown Affiliation
Presbitero, Patrizia
Unknown Affiliation
Rossi, Marco Luciano
Unknown Affiliation
Fanelli, Raffaele
Unknown Affiliation
Airoldi, Flavio
Unknown Affiliation
Tavano, Davide
Unknown Affiliation
Caso, Pio
Unknown Affiliation
Sim, Kui Hian
Unknown Affiliation
Badings, Erik A.
Unknown Affiliation
Nierop, Pieter R.
Unknown Affiliation
Ronner, Eelko F.
Unknown Affiliation
van 't Hof, Arnoud W.J.
Unknown Affiliation
Dunselman, Peter H.J.M.
Unknown Affiliation
Liem, Anho
Unknown Affiliation
Nijmeijer, Remco
Unknown Affiliation
Groenemeijer, Björn E.
Unknown Affiliation
Koolen, Jacques J.
Unknown Affiliation
Scott, Robert A.
Unknown Affiliation
Devlin, Gerard P.
Unknown Affiliation
Stewart, Ralph A.H.
Unknown Affiliation
Hamer, Andrew W.
Unknown Affiliation
Turner, Anne M.
Unknown Affiliation
Atar, Dan
Unknown Affiliation
Graven, Torbjørn
Unknown Affiliation
Halvorsen, Sigrun
Unknown Affiliation
Gullestad, Lars Lysgaard
Unknown Affiliation
Søyland, Elisabeth
Unknown Affiliation
Medina, Félix A.
Unknown Affiliation
Huapalla, Edith Chavez
Unknown Affiliation
Torres, Ferran L.
Unknown Affiliation
Statistics
Citations: 3,142
Authors: 286
Affiliations: 9
Identifiers
Doi:
10.1056/NEJMoa1410489
ISSN:
00284793
Research Areas
Cancer
Disability
Environmental
Noncommunicable Diseases
Study Design
Randomised Control Trial
Cohort Study