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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Higher levels of hepatitis C virus RNA found in blood donors co-infected with HIV as compared to HCV mono-infected donors
Journal of Infection in Developing Countries, Volume 8, No. 8, Year 2014
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Description
Introduction: Hepatitis C virus (HCV) infection and human immunodeficiency virus (HIV) infections are public health problems in sub-Saharan countries such as the Republic of Congo. HIV infection could impact the characteristics of HCV infection in co-infected people. We investigated HCV-HIV co-infection among blood donors in Congo. Methodology: Ninety-nine HIV-positive and/or HCV-seropositive blood donors were selected during screening and subsequently tested for aminotransferases and HCV RNA. Results: A total of 29 donors were found positive for HCV RNA (HCV-infected individuals), including 19/60 (31.66%) HIV donors (coinfected) and 10/39 (25.64%) non-HIV donors (mono-infected). Most of the co-infected donors (17/19) displayed a high viral load (> 5 log). The median HCV RNA level was at least 2 logs higher in co-infected people. The levels of alanine aminotransferase (ALT) were also slightly higher in co-infected donors than in HCV mono-infected donors. Conclusion: This study reports HCV-HIV co-infection among blood donors in Congo and shows that HCV viral load is higher in HIV donors. © 2014 Alidjinou et al.
Authors & Co-Authors
Alidjinou, Enagnon Kazali
France, Lille
Laboratoire de Virologie
Moukassa, Donatien
Congo
Hôpital Général de Loandjili
Ebatetou-Ataboho, E.
Congo
Hôpital Général de Loandjili
Mahoungou, Gaël Honal
Congo
Hôpital Général de Loandjili
Pambou, Jean Paul
Congo
Centre Inter-départemental de Transfusion Sanguine (cidts)
Sane, F.
France, Lille
Laboratoire de Virologie
Prevost, Brigitte
France, Lille
Laboratoire de Virologie
Bocket, Laurence
France, Lille
Laboratoire de Virologie
Ibara, Jean Rosaire
Congo, Brazzaville
Centre Hospitalier et Universitaire de Brazzaville
Hober, Didier
France, Lille
Laboratoire de Virologie
Statistics
Citations: 10
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.3855/jidc.4767
Research Areas
Infectious Diseases
Study Locations
Congo