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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Clinical significance of serum expression of GROβ in esophageal squamous cell carcinoma
World Journal of Gastroenterology, Volume 17, No. 21, Year 2011
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Description
Aim: To determine the association between serum levels of growth-related gene product β (GROβ) and clinical parameters in esophageal squamous cell carcinoma (ESCC). Methods: Using enzyme-linked immunosorbent assay, serum GROβ levels were measured in ESCC patients (n = 72) and healthy volunteers (n = 83). The association between serum levels of GROβ and clinical parameters of ESCC was analyzed statistically. Results: The serum GROβ levels were much higher in ESCC patients than in healthy controls (median: 645 ng/L vs 269 ng/L, P < 0.05). Serum GROβ levels were correlated positively with tumor size, lymph node metastasis, and tumor-node-metastasis (TNM) staging, but not with gender or the histological grade of tumors in ESCC patients. The sensitivity and specificity of the assay for serum GROβ were 73.61% and 56.63%, respectively. Conclusion: GROβ may function as an oncogene product and contribute to tumorigenesis and metastasis of ESCC. © 2011 Baishideng.
Authors & Co-Authors
Dong, Qiao Mei
Unknown Affiliation
Zhang, Jin Qiang
Unknown Affiliation
Li, Qian
Unknown Affiliation
Bracher, Jacqueline
Unknown Affiliation
Hendricks, Denver T.
Unknown Affiliation
Zhao, Xiaohang
Unknown Affiliation
Statistics
Citations: 16
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.3748/wjg.v17.i21.2658
ISSN:
10079327
Research Areas
Cancer
Genetics And Genomics