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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Apparently non-expressed alleles of factor B (BF) code for hypomorphic proteins
Immunogenetics, Volume 37, No. 1, Year 1992
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Description
In three families with an apparent non-expressed factor B (BF) allele (BF*Q0), advanced methods of isoelectric focusing for the determination of BF F subtypes revealed different hypomorphic BF products (BF QL) with functional hemolytic activity expressed by the assumed BF*Q0 allele. A Taq I and a Msp I restriction fragment length polymorphism as well as the Ba fragment of the expression products showed banding patters for the BF*QL alleles corresponding to BF S types, whereas an altered Bb fragment was seen in two BF QL products. In one family an intragenic recombination site within the Bb part of the BF gene was assumed. Investigations of factor B and its conversion fragments, as demonstrated by the used methods, allow to complement molecular genetic investigations of BF*Q0 alleles in heterozygous genotypes on a protein level. We conclude that apparently non-expressed alleles of factor B code for hypomorphic but functionally active proteins. © 1992 Springer-Verlag.
Authors & Co-Authors
Siemens, Ingbert
Germany, Heidelberg
Universität Heidelberg
Brenden, Martina
Germany, Koln
Universität zu Köln
Mauff, Gottfried
Germany, Koln
Universität zu Köln
Abbal, Michel
France, Toulouse
Hôpital Purpan
Du Toit, Ernette D.
South Africa, Cape Town
University of Cape Town
Bertrams, Jörg
Germany, Essen
Elisabeth-krankenhaus Essen
Geserick, Günther
Germany, Berlin
Humboldt-universität zu Berlin
Statistics
Citations: 7
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1007/BF00223541
ISSN:
00937711
e-ISSN:
14321211
Research Areas
Genetics And Genomics