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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Synchronous cycles of domestic dog rabies in sub-Saharan Africa and the impact of control efforts
Proceedings of the National Academy of Sciences of the United States of America, Volume 104, No. 18, Year 2007
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Description
Rabies is a fatal neurological pathogen that is a persistent problem throughout the developing world where it is spread primarily by domestic dogs. Although the disease has been extensively studied in wildlife populations in Europe and North America, the dynamics of rabies in domestic dog populations has been almost entirely neglected. Here, we demonstrate that rabies epidemics in southern and eastern Africa cycle with a period of 3-6 years and show significant synchrony across the region. The observed period is shorter than predictions based on epidemiological parameters for rabies in domestic dogs. We find evidence that rabies prevention measures, including vaccination, are affected by disease prevalence and show that a simple model with intervention responses can capture observed disease periodicity and host dynamics. We suggest that movement of infectious or latent animals combined with coordinated control responses may be important in coupling populations and generating synchrony at the continental scale. These findings have important implications for rabies prediction and control: large-scale synchrony and the importance of intervention responses suggest that control of canine rabies in Africa will require sustained efforts coordinated across political boundaries. © 2007 by The National Academy of Sciences of the USA.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC1863501/bin/pnas_0609122104_index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC1863501/bin/pnas_0609122104_4.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1863501/bin/pnas_0609122104_1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1863501/bin/pnas_0609122104_2.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1863501/bin/pnas_0609122104_3.pdf
Authors & Co-Authors
Hampson, Katie
United States, Princeton
Princeton University
Dushoff, Jonathan G.
United States, Princeton
Princeton University
United States, Bethesda
National Institutes of Health Nih
Bingham, John
Australia, Geelong
Australian Centre for Disease Preparedness
Brückner, Gideon K.
South Africa, Elsenburg
Directorate of Veterinary Services
Ali, Yahia Hassan
Sudan, Khartoum
Central Veterinary Research Laboratory Sudan
Dobson, Andrew D.M.
United States, Princeton
Princeton University
Statistics
Citations: 148
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1073/pnas.0609122104
ISSN:
00278424
Study Design
Randomised Control Trial
Cross Sectional Study