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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of different asthma treatments on risk of cold-related exacerbations
European Respiratory Journal, Volume 38, No. 3, Year 2011
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Description
Common colds often trigger asthma exacerbations. The present study compared cold-related severe exacerbations during budesonide/formoterol maintenance and reliever therapy, and different regimens of maintenance inhaled corticosteroids (ICS), with or without long-acting β 2-agonists (LABA), and with as-needed short-acting β 2-agonists (SABA) or LABA. Reported colds and severe exacerbations (defined by oral corticosteroid use and/or hospitalisation/emergency room visit) were assessed for 12,507 patients during 6-12 months of double-blind treatment. Exacerbations occurring ≤14 days after onset of reported colds were analysed by a Poisson model. The incidence of colds was similar across treatments. Asthma symptoms and reliever use increased during colds. Budesonide/formoterol maintenance and reliever therapy reduced severe cold-related exacerbations by 36% versus pooled comparators plus SABA (rate ratio (RR) 0.64; p=0.002), and for individual treatment comparisons, by 52% versus the same maintenance dose of ICS/LABA (RR 0.48; p<0.001); there were nonsignificant reductions versus higher maintenance doses of ICS or ICS/LABA (RR 0.83 and 0.72, respectively). As-needed LABA did not reduce cold-related exacerbations versus as-needed SABA (RR 0.96). Severe cold-related exacerbations were reduced by budesonide/formoterol maintenance and reliever therapy compared with ICS with or without LABA and with as-needed SABA. Subanalyses suggested the importance of the ICS component in reducing cold-related exacerbations. Future studies should document the cause of exacerbations, in order to allow identification of different treatment effects. Copyright©ERS 2011.
Authors & Co-Authors
Reddel, Helen K.
Australia, Sydney
The University of Sydney
Jenkins, Christine R.
Australia, Sydney
The University of Sydney
Quirce, Santiago
Spain, Madrid
Universidad Autónoma de Madrid
Sears, Malcolm R.
Canada, Hamilton
Michael G. Degroote School of Medicine
Bateman, E. D.
South Africa, Cape Town
University of Cape Town
O'Byrne, Paul M.
Canada, Hamilton
Michael G. Degroote School of Medicine
Humbert, Marc
France, Clamart
Hopital Antoine Beclere
Buhl, Roland Otto
Germany, Mainz
Universitätsmedizin Mainz
Harrison, Tim W.
United Kingdom, Nottingham
University of Nottingham
Brusselle, Guy G.
Belgium, Ghent
Universitair Ziekenhuis Gent
Thorén, A.
Sweden, Lund
Skånes Universitetssjukhus
Sjöbring, U.
Sweden, Lund
Skånes Universitetssjukhus
Peterson, Stefan
Sweden, Lund
Skånes Universitetssjukhus
Östlund, Ollie
Sweden, Lund
Skånes Universitetssjukhus
Eriksson, Göran
Sweden, Lund
Skånes Universitetssjukhus
Statistics
Citations: 15
Authors: 15
Affiliations: 9
Identifiers
Doi:
10.1183/09031936.00186510
ISSN:
09031936
e-ISSN:
13993003
Research Areas
Disability
Health System And Policy
Study Design
Cohort Study