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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Obese children and adolescents have elevated nighttime blood pressure independent of insulin resistance and arterial stiffness
American Journal of Hypertension, Volume 27, No. 11, Year 2014
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Description
RESULTS Mean ± SD daytime systolic BP (SBP) (obese: 125±8.3mm Hg; control: 121±10.1mm Hg; P = 0.03) and nighttime SBP (obese: 108±10.7mm Hg; control: 102±8.2mm Hg; P = 0.0001) were higher in the obese group when compared with the control group. No difference was found in daytime diastolic BP (DBP), whereas nighttime DBP (obese: 60±6.6mm Hg; control: 57±4.8mm Hg; P = 0.001) and night-to-day BP ratios were higher in the obese group. Nighttime SBP was related to BMI z score (β = 6.0; 95% confidence interval (CI) = 2.9-9.1; P = 0.0002) and waist/height ratio (β = 36.7; 95% CI = 5.6-67.9; P = 0.02) in the obese group. HOMA index (obese: median = 3.7, interquartile range (IQR) = 2.3-6.0; control: median = 2.6, IQR = 1.8-3.4; P = 0.002) was higher, whereas cfPWV (obese: 4.8±0.8 m/s; control: 5.1±0.6 m/s; P = 0.03) was lower in the obese group. CfPWV was not related to logHOMA index. In multiple regression analyses, the higher nighttime BP in the obese group was independent of logHOMA and cfPWV.; CONCLUSIONS Obese children had a higher nighttime BP when compared with the control group independently of insulin resistance and arterial stiffness.; BACKGROUND Insulin resistance has been related to elevated blood pressure (BP) in obese children and may adversely affect the vasculature by arterial stiffening. The objective was to investigate whether daytime and nighttime BP were elevated and related to insulin resistance and arterial stiffness in obese children and adolescents.; METHODS Ninety-two obese patients aged 10-18 years were compared with 49 healthy control individuals. Insulin resistance was measured as the homeostatic assessment model (HOMA), and arterial stiffness was measured as carotid-femoral pulse wave velocity (cfPWV). © 2014 American Journal of Hypertension, Ltd. All rights reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4263935/bin/supp_27_11_1408__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC4263935/bin/supp_hpu055_ONLINE_SUPPLEMENTARY_TABLE_2.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC4263935/bin/supp_hpu055_ONLINE_SUPPLEMENTARY_TABLE_1.doc
Authors & Co-Authors
Hvidt, Kristian Nebelin
Denmark, Copenhagen
Copenhagen University Hospital
Olsen, Michael Hecht
South Africa, Potchefstroom
North-west University
Holm, Jens Christian
Denmark, Copenhagen
Copenhagen University Hospital
Ibsen, Hans Henning Windeløv
Denmark, Copenhagen
Copenhagen University Hospital
Statistics
Citations: 25
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1093/ajh/hpu055
ISSN:
08957061
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Study Design
Randomised Control Trial