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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure
Human Molecular Genetics, Volume 28, No. 15, Year 2019
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Description
Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene-smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and/or diastolic BP through gene-smoking interaction analysis and 38 were newly identified (P < 5 × 10-8, false discovery rate < 0.05). We also identified nine new signals near known loci. Of the 136 loci, 8 showed significant interaction with smoking status. They include CSMD1 previously reported for insulin resistance and BP in the spontaneously hypertensive rats. Many of the 38 new loci show biologic plausibility for a role in BP regulation. SLC26A7 encodes a chloride/bicarbonate exchanger expressed in the renal outer medullary collecting duct. AVPR1A is widely expressed, including in vascular smooth muscle cells, kidney, myocardium and brain. FHAD1 is a long non-coding RNA overexpressed in heart failure. TMEM51 was associated with contractile function in cardiomyocytes. CASP9 plays a central role in cardiomyocyte apoptosis. Identified only in African ancestry were 30 novel loci. Our findings highlight the value of multi-ancestry investigations, particularly in studies of interaction with lifestyle factors, where genomic and lifestyle differences may contribute to novel findings. © 2019 The Author(s). Published by Oxford University Press. All rights reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC6644157/bin/smoking-map-pp_s_tables_12-18-2018.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC6644157/bin/smoking-map-pp_suppl_all_03-21-2019.pdf
Authors & Co-Authors
Sung, Yunju
United States, St. Louis
Washington University School of Medicine in St. Louis
de las Fuentes, Lisa
United States, St. Louis
Washington University School of Medicine in St. Louis
United States, St. Louis
Washington University in St. Louis
Winkler, Thomas W.
Germany, Regensburg
Universität Regensburg
Chasman, Daniel I.
United States, Boston
Brigham and Women's Hospital
Bentley, Amy Rebecca
United States, Bethesda
National Institutes of Health Nih
Kraja, Aldi T.
United States, St. Louis
Washington University School of Medicine in St. Louis
Ntalla, Ioanna
United Kingdom, London
Queen Mary University of London
Warren, Helen R.
United Kingdom, London
Queen Mary University of London
Guo, Xiuqing
United States, Torrance
The Lundquist Institute
Schwander, Karen L.
United States, St. Louis
Washington University School of Medicine in St. Louis
Manning, Alisa Knodle
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Massachusetts Institute of Technology
Brown, Michael R.
United States, Houston
University of Texas School of Public Health
Aschard, Hugues
United States, Boston
Harvard T.h. Chan School of Public Health
France, Paris
Institut Pasteur, Paris
Feitosa, Mary Furlan
United States, St. Louis
Washington University School of Medicine in St. Louis
Franceschini, Nora
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Lu, Yingchang
United States, New York
Icahn School of Medicine at Mount Sinai
Cheng, Ching Yu
Singapore, Singapore City
Singapore National Eye Centre
Singapore, Singapore City
Duke-nus Medical School
Singapore, Singapore City
National University of Singapore
Sim, Xueling
Singapore, Singapore City
National University of Singapore
Vojinovic, Dina
Netherlands, Rotterdam
Erasmus Mc
Marten, Jonathan
United Kingdom, Edinburgh
The University of Edinburgh
Musani, Solomon K.
Unknown Affiliation
Kilpeläinen, Tuomas Oskari
Denmark, Copenhagen
Københavns Universitet
United States, New York
Icahn School of Medicine at Mount Sinai
Richard, Melissa A.
United States, Houston
University of Texas Health Science Center at Houston
Aslibekyan, Stella
United States, Birmingham
The University of Alabama at Birmingham
Bartz, Traci M.
United States, Seattle
University of Washington
Dorajoo, R. S.O.
Singapore, Singapore City
Agency for Science, Technology and Research, Singapore
Li, Changwei
United States, Athens
University of Georgia
Liu, Yongmei
United States, Winston Salem
Wake Forest University Health Sciences
Smith, Albert Vernon
Iceland, Kopavogur
Icelandic Heart Association
Iceland, Reykjavik
Haskoli Islands
Tajuddin, Salman M.
United States, Bethesda
National Institutes of Health Nih
Tayo, Bamidele O.
United States, Chicago
Loyola University Chicago
Zhao, Wei
United States, Ann Arbor
University of Michigan, Ann Arbor
Sofer, Tamar
United States, Boston
Harvard Medical School
United States, Boston
Brigham and Women's Hospital
Alver, Maris
Estonia, Tartu
Tartu Ülikool
Boissel, Mathilde
France, Lille
Institut Pasteur de Lille
Chai, Jinfang
Singapore, Singapore City
National University of Singapore
Divers, Jasmin
United States, Winston Salem
Wake Forest University School of Medicine
Gandin, Ilaria
Italy, Trieste
Università Degli Studi Di Trieste
Giulianini, Franco
United States, Boston
Brigham and Women's Hospital
Goel, Anuj
United Kingdom, Oxford
University of Oxford
Harris, Sarah E.
United Kingdom, Edinburgh
The University of Edinburgh
Hartwig, Fernando Pires
Brazil, Pelotas
Universidade Federal de Pelotas
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
Hsu, Fangchi
United States, Winston Salem
Wake Forest University School of Medicine
Jackson, Anne U.
United States, Pittsburgh
University of Pittsburgh
Kasturiratne, Anuradhani
Finland, Kuopio
Itä-suomen Yliopisto
Komulainen, Pirjo
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Kühnel, Brigitte
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Sweden, Stockholm
Karolinska Institutet
Leander, Karin
Taiwan, Taichung
Veterans General Hospital-taichung Taiwan
Lee, Wen Jane
Taiwan, Taichung
Veterans General Hospital-taichung Taiwan
Luan, Jian'fan N.An
Finland, Tampere
Fimlab Laboratoriot oy
Lyytikäinen, Leo Pekka
Finland, Tampere
Tampere University
Jamaica, Kingston
The University of the West Indies
McKenzie, Colin A.
China, Wuhan
Huazhong University of Science and Technology
Nelson, Christopher P.
United Kingdom, Leicester
University of Leicester
Noordam, Raymond
Netherlands, Leiden
Leids Universitair Medisch Centrum
Scott, Robert A.
Finland, Tampere
Fimlab Laboratoriot oy
Sheu, Wayne Huey Herng
Taiwan, Taichung
Veterans General Hospital-taichung Taiwan
Taiwan, Taipei
National Yang-ming University Taiwan
Taiwan, Taipei
National Defense Medical Center Taiwan
Taiwan, Taichung
National Chung Hsing University
Stančáková, Alena
Finland, Kuopio
Itä-suomen Yliopisto
Takeuchi, Fumihiko
Japan, Tokyo
National Center for Global Health and Medicine
van der Most, Peter J.
Netherlands, Groningen
Rijksuniversiteit Groningen
Varga, Tibor V.
Sweden, Lund
Skånes Universitetssjukhus
Wang, Heming
United States, Boston
Harvard Medical School
United States, Boston
Brigham and Women's Hospital
Ware, Erin B.
United States, Ann Arbor
University of Michigan, Ann Arbor
Weiss, Stefan
Germany, Greifswald
Universitätsmedizin Greifswald
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Yanek, Lisa R.
United States, Baltimore
Johns Hopkins School of Medicine
Zhang, Weihua
United Kingdom, London
Mrc Centre for Environment and Health
United Kingdom, Southall
Ealing Hospital
Zhao, Jinghua
Finland, Tampere
Fimlab Laboratoriot oy
Afaq, Saima
United Kingdom, London
Mrc Centre for Environment and Health
Alfred, Tamuno
United States, New York
Icahn School of Medicine at Mount Sinai
Amin, Najaf A.
Netherlands, Rotterdam
Erasmus Mc
Arking, Dan E.
United States, Baltimore
Johns Hopkins Medicine
Aung, Tin
Singapore, Singapore City
Singapore National Eye Centre
Singapore, Singapore City
Duke-nus Medical School
Singapore, Singapore City
National University of Singapore
Barr, RGraham
United States, New York
Columbia University Irving Medical Center
Bielak, Lawrence F.
United States, Ann Arbor
University of Michigan, Ann Arbor
Boerwinkle, Eric A.
United States, Houston
University of Texas School of Public Health
United States, Houston
Baylor College of Medicine
Böttinger, Erwin P.
United States, New York
Icahn School of Medicine at Mount Sinai
Braund, Peter S.
United Kingdom, Leicester
University of Leicester
Brody, Jennifer A.
United States, Seattle
University of Washington
Broeckel, Ulrich
United States, Milwaukee
Medical College of Wisconsin
Cade, Brian E.
United States, Boston
Brigham and Women's Hospital
Campbell, Archie I.
United Kingdom, Edinburgh
The University of Edinburgh
Canouil, Mickaël
France, Lille
Institut Pasteur de Lille
Chakravarti, Aravinda
United States, Baltimore
Johns Hopkins Medicine
Collins, Francis S.
United States, Bethesda
National Institutes of Health Nih
Connell, John M.C.
United Kingdom, Dundee
University of Dundee
de Mutsert, Renée
Netherlands, Leiden
Leids Universitair Medisch Centrum
de Silva, Hithanadura Janaka
Sri Lanka, Kelaniya
University of Kelaniya
Dörr, Marcus
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Germany, Greifswald
Universitätsmedizin Greifswald
Duan, Qing
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Eaton, Charles B.
United States, Providence
The Warren Alpert Medical School
Ehret, Georg B.
United States, Baltimore
Johns Hopkins Medicine
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Evangelou, Evangelos
United Kingdom, London
Mrc Centre for Environment and Health
Greece, Ioannina
Faculty of Medicine
Faul, Jessica D.
United States, Ann Arbor
University of Michigan, Ann Arbor
Forouhi, Nita G.
Finland, Tampere
Fimlab Laboratoriot oy
Franco, Oscar H.
Netherlands, Rotterdam
Erasmus Mc
Friedlander, Yechiel
Israel, Jerusalem
Hebrew University of Jerusalem
Gao, He
United Kingdom, London
Mrc Centre for Environment and Health
Gigante, Bruna
Taiwan, Taichung
Veterans General Hospital-taichung Taiwan
Gu, C. Charles
United States, St. Louis
Washington University School of Medicine in St. Louis
Hagenaars, Saskia P.
United Kingdom, Edinburgh
The University of Edinburgh
Harris, Tamara B.
United States, Bethesda
National Institutes of Health Nih
He, Jiang
United States, New Orleans
Tulane University School of Public Health and Tropical Medicine
United States, New Orleans
Tulane University School of Medicine
Hofman, Albert
Netherlands, Rotterdam
Erasmus Mc
Howard, Barbara V.
United States, Hyattsville
Medstar Health Research Institute
United States, Washington, D.c.
Georgetown-howard Universities Center for Clinical and Translational Science
Hunt, Steven C.
United States, Salt Lake City
University of Utah School of Medicine
Qatar, Doha
Weill Cornell Medicine-qatar
Irvin, Marguerite Ryan
United States, Birmingham
The University of Alabama at Birmingham
Jia, Yucheng
United States, Torrance
The Lundquist Institute
Khor, Chiea Chuen
Singapore, Singapore City
Agency for Science, Technology and Research, Singapore
Singapore, Singapore City
National University of Singapore
Koh, Woon Puay
Singapore, Singapore City
National University of Singapore
Singapore, Singapore City
Duke-nus Medical School
Koistinen, Heikki A.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Finland, Helsinki
Helsingin Yliopisto
Finland, Helsinki
Biomedicum Helsinki
Kooperberg, Charles B.
United States, Seattle
Fred Hutchinson Cancer Center
Krieger, Jose E.
United States, Ann Arbor
University of Michigan, Ann Arbor
Kubo, Michiaki
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Kutalik, Zoltán
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Kuusisto, Johanna K.
Finland, Kuopio
Itä-suomen Yliopisto
Lakka, Timo Antero
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Finland, Kuopio
Itä-suomen Yliopisto
Finland, Kuopio
Kuopio University Hospital
Langefeld, Carl D.
United States, Winston Salem
Wake Forest University School of Medicine
Langenberg, Claudia C.
Finland, Tampere
Fimlab Laboratoriot oy
Launer, Lenore J.
United States, Bethesda
National Institutes of Health Nih
Lehne, Benjamin C.
United Kingdom, London
Mrc Centre for Environment and Health
Levy, Daniel A.
United States, Framingham
Framingham Heart Study
United States, Bethesda
National Institutes of Health Nih
Lewis, Cora Elizabeth
United States, Birmingham
The University of Alabama at Birmingham
Liu, Chingti
United States, Boston
School of Public Health
Liu, Jianjun
Singapore, Singapore City
National University of Singapore
Singapore, Singapore City
Agency for Science, Technology and Research, Singapore
Loh, Marie Chiew Shia
United Kingdom, London
Mrc Centre for Environment and Health
Singapore, Singapore City
Agency for Science, Technology and Research, Singapore
Lohman, Kurt K.
United States, Winston Salem
Wake Forest University School of Medicine
Louie, Tin L.
United States, Seattle
University of Washington
Mägi, Reedik
Estonia, Tartu
Tartu Ülikool
Matsuda, Koichi
Japan, Tokyo
The University of Tokyo
Meitinger, Thomas A.
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Technische Universität München
Metspalu, Andres H.
Estonia, Tartu
Tartu Ülikool
Milani, Lili
United States, St. Louis
Washington University in St. Louis
Momozawa, Yukihide
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Mosley, Thomas H.
United States, University
University of Mississippi
Nalls, Mike A.
United States, Bethesda
National Institute on Aging Nia
O'Connell, Jeffrey R.
United States, Baltimore
University of Maryland School of Medicine
Ogunniyi, Adesola O.
Nigeria, Ibadan
University of Ibadan
Palmas, Walter R.
United States, New York
Columbia University
Palmer, Nicholette (Nichole)
United States, Winston Salem
Wake Forest University School of Medicine
Pankow, Jim S.
United States, Minneapolis
School of Public Health
Pedersen, Nancy Lee
Sweden, Stockholm
Karolinska Institutet
Peters, Annette Michael
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Peyser, Patricia A.
United States, Ann Arbor
University of Michigan, Ann Arbor
Polašek, Ozren
Croatia, Split
School of Medicine, University of Split
Croatia, Zagreb
Klinika za Psihijatriju Sveti Ivan
Porteous, David John
United Kingdom, Edinburgh
The University of Edinburgh
Raitakari, Olli T.
Finland, Turku
Turun Yliopistollinen Keskussairaala
Finland, Turku
Turun Yliopisto
Renström, Frida
Sweden, Lund
Skånes Universitetssjukhus
Sweden, Umea
Umeå Universitet
Ridker, Paul M.
United States, Boston
Brigham and Women's Hospital
Robino, Antonietta
Italy, Trieste
Irccs Burlo Garofolo
Robinson, Jennifer G.
United States, Iowa City
University of Iowa
Rose, Lynda M.
United States, Boston
Brigham and Women's Hospital
Rudan, Igor
United Kingdom, Edinburgh
The University of Edinburgh
Salako, Babatunde Lawal
Nigeria, Ibadan
University of Ibadan
Schreiner, Pamela J.
United States, Minneapolis
School of Public Health
Scott, William R.
United Kingdom, London
Mrc Centre for Environment and Health
United Kingdom, London
Imperial College London
Sever, Peter S.
United Kingdom, London
Imperial College London
Sitlani, Colleen M.
United States, Seattle
University of Washington
Smith, Blair H.
United Kingdom, Dundee
University of Dundee
Smith, Jennifer Anne
United States, Ann Arbor
University of Michigan, Ann Arbor
Snieder, Harold
Netherlands, Groningen
Rijksuniversiteit Groningen
Starr, John Michael
United Kingdom, Edinburgh
The University of Edinburgh
Strauch, Konstantin
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Ludwig-maximilians-universität München
Tang, Hua
United States, Palo Alto
Stanford University
Taylor, Kent D.
United States, Torrance
The Lundquist Institute
Teo, Yik Ying
Singapore, Singapore City
National University of Singapore
Singapore, Singapore City
Agency for Science, Technology and Research, Singapore
Uitterlinden, André G.
Netherlands, Rotterdam
Erasmus Mc
Waldenberger, Melanie
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
United Kingdom, Cambridge
Mrc Epidemiology Unit
Wang, Lihua
United States, St. Louis
Washington University School of Medicine in St. Louis
Wang, Yaxing
China, Beijing
Beijing Institute of Ophthalmology
Wojczynski, Mary K.
United States, St. Louis
Washington University School of Medicine in St. Louis
Xiang, Yongbing
China, Shanghai
Shanghai Cancer Institute
Yao, Jie
United States, Torrance
The Lundquist Institute
Yuan, Jianmin
United States, Pittsburgh
University of Pittsburgh
Zonderman, Alan B.
United States, Bethesda
National Institutes of Health Nih
Becker, Diane M.
United States, Baltimore
Johns Hopkins School of Medicine
Boehnke, Michael L.
United States, Ann Arbor
University of Michigan, Ann Arbor
Bowden, Donald W.
United States, Winston Salem
Wake Forest University School of Medicine
Chambers, John Campbell
United Kingdom, London
Mrc Centre for Environment and Health
United Kingdom, Southall
Ealing Hospital
Chen, Yii Der Ida
United States, Torrance
The Lundquist Institute
Weir, David R.
United States, Ann Arbor
University of Michigan, Ann Arbor
Dé Fairé, Ulf H.
Sweden, Stockholm
Karolinska Institutet
Deary, Ian J.
United Kingdom, Edinburgh
The University of Edinburgh
Esko, Tönu
Estonia, Tartu
Tartu Ülikool
United States, Cambridge
Harvard University
Farrall, Martin
United Kingdom, Oxford
University of Oxford
Forrester, Terrence E.
Jamaica, Kingston
The University of the West Indies
Freedman, Barry I.
United States, Winston Salem
Wake Forest University School of Medicine
Froguel, Philippe
France, Lille
Institut Pasteur de Lille
United Kingdom, London
Imperial College London
Gasparini, Paolo P.
Italy, Trieste
Università Degli Studi Di Trieste
Qatar, Doha
Weill Cornell Medicine-qatar
Gieger, Christian
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Oberschleissheim
Deutsches Zentrum Für Diabetesforschung
Horta, Bernardo Lessa
Brazil, Pelotas
Universidade Federal de Pelotas
Hung, Yijen
Taiwan, Taipei
National Defense Medical Center Taiwan
Jonas, Jost Bruno
China, Beijing
Capital Medical University
Germany, Heidelberg
Universität Heidelberg
Kato, Norihiro
Japan, Tokyo
National Center for Global Health and Medicine
Kooner, Jaspal Singh
United Kingdom, Southall
Ealing Hospital
United Kingdom, London
Imperial College London
Laakso, M. M.
Finland, Kuopio
Itä-suomen Yliopisto
Lehtimäki, Terho J.
Finland, Tampere
Fimlab Laboratoriot oy
Finland, Tampere
Tampere University
Magnusson, Patrik K.E.
Sweden, Stockholm
Karolinska Institutet
Oldehinkel, Albertine J.(Tineke)
Netherlands, Groningen
Rijksuniversiteit Groningen
Pereira, Alexandre Da Costa
Brazil, Sao Paulo
Universidade de São Paulo
United States, Boston
Harvard Medical School
Perls, Thomas T.
United States, Boston
Boston University Medical Center
Rauramaa, Rainer
Finland, Kuopio
Itä-suomen Yliopisto
Redline, Susan S.
United States, Boston
Brigham and Women's Hospital
Rettig, Rainer
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Germany, Greifswald
Universitätsmedizin Greifswald
Samani, Nilesh J.
United Kingdom, Leicester
University of Leicester
Scott, James M.
United Kingdom, London
Imperial College London
Shu, Xiaoou
United States, Nashville
Vanderbilt University School of Medicine
van der Harst, Pim
Netherlands, Groningen
Rijksuniversiteit Groningen
Wagenknecht, Lynne E.
United States, Winston Salem
Wake Forest University School of Medicine
Wareham, Nicholas J.
United Kingdom, Cambridge
Mrc Epidemiology Unit
Watkins, Hugh C.
United Kingdom, Oxford
University of Oxford
Wickramasinghe, Ananda Rajitha
Sri Lanka, Kelaniya
University of Kelaniya
Wu, Tangchun
China, Wuhan
Huazhong University of Science and Technology
Kamatani, Yoichiro
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Laurie, Cathy C.
United States, Seattle
University of Washington
Bouchard, Claude E.
United States, Baton Rouge
Pennington Biomedical Research Center
Cooper, Richard S.
United States, Chicago
Loyola University Chicago
Evans, Michele Kim
United States, Bethesda
National Institutes of Health Nih
Gudnason, V. G.
Iceland, Kopavogur
Icelandic Heart Association
Iceland, Reykjavik
Haskoli Islands
Kardia, Sharon L.R.
United States, Ann Arbor
University of Michigan, Ann Arbor
Kritchevsky, Stephen B.
United States, Winston Salem
Wake Forest University School of Medicine
Psaty, Bruce M.
United States, Seattle
University of Washington
United States, Oakland
Kaiser Permanente
van Dam, Robertus Martinus
Singapore, Singapore City
National University of Singapore
Arnett, Donna K.
United States, Lexington
College of Public Health
Mook-Kanamori, Dennis Owen
Netherlands, Leiden
Leids Universitair Medisch Centrum
Fornage, Myriam
United States, Houston
University of Texas Health Science Center at Houston
Fox, Ervin R.
United States, Jackson
University of Mississippi Medical Center
Hayward, Caroline
United Kingdom, Edinburgh
The University of Edinburgh
van Duijn, Cornelia M.
Netherlands, Rotterdam
Erasmus Mc
Tai, E. Shyong
Singapore, Singapore City
National University of Singapore
Singapore, Singapore City
Duke-nus Medical School
Wong, Tienyin
Singapore, Singapore City
Singapore National Eye Centre
Singapore, Singapore City
Duke-nus Medical School
Singapore, Singapore City
National University of Singapore
Loos, Ruth J.F.
United States, New York
Icahn School of Medicine at Mount Sinai
Reiner, Alexander Paul
United States, Seattle
Fred Hutchinson Cancer Center
Rotimi, Charles N.
United States, Bethesda
National Institutes of Health Nih
Bierut, Laura Jean
United States, St. Louis
Washington University School of Medicine in St. Louis
Cupples, Laura Adrienne
United States, Boston
School of Public Health
Province, Michael A.
United States, St. Louis
Washington University School of Medicine in St. Louis
Rotter, Jerome I.
United States, Torrance
The Lundquist Institute
Franks, Paul W.
Sweden, Lund
Skånes Universitetssjukhus
United States, Cambridge
Harvard University
Sweden, Umea
Umeå Universitet
Rice, Kenneth Martin
United States, Seattle
University of Washington
Elliott, Paul E.
United Kingdom, London
Mrc Centre for Environment and Health
Caulfield, Mark J.
United Kingdom, London
Queen Mary University of London
Gauderman, William James
United States, Los Angeles
University of Southern California
Munroe, Patricia B.
United Kingdom, London
Queen Mary University of London
Rao, Dabeeru C.
United States, St. Louis
Washington University School of Medicine in St. Louis
Morrison, Alanna C.
United States, Houston
University of Texas School of Public Health
Statistics
Citations: 22
Authors: 244
Affiliations: 124
Identifiers
Doi:
10.1093/hmg/ddz070
ISSN:
09646906
Research Areas
Cancer
Genetics And Genomics
Noncommunicable Diseases
Substance Abuse
Study Design
Cohort Study