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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
environmental science
Evaluation of anticoagulant rodenticide sensitivity by examining in vivo and in vitro responses in avian species, focusing on raptors
Environmental Pollution, Volume 341, Article 122837, Year 2024
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Description
Anticoagulant rodenticides (ARs) are used to control pest rodent species but can result in secondary poisoning of non-target animals, especially raptors. In the present study, differences in AR sensitivity among avian species were evaluated by comparing in vivo warfarin pharmacokinetics and effects, measuring cytochrome P450s (CYPs) expression involved in AR metabolism, and conducting in vitro inhibition assays of the AR target enzyme Vitamin K 2,3-epoxide reductase (VKOR). Oral administration of warfarin at 4 mg/kg body weight did not prolong prothrombin time in chickens (Gallus gallus), rock pigeons (Columba livia), or Eastern buzzards (Buteo japonicus). Rock pigeons and buzzards exhibited shorter plasma half-life of warfarin compared to chickens. For the metabolite analysis, 4′-hydroxywarfarin was predominantly detected in all birds, while 10-hydroxywarfarin was only found in pigeons and raptors, indicating interspecific differences in AR metabolism among birds likely due to differential expression of CYP enzymes involved in the metabolism of ARs and variation of VKOR activities among these avian species. The present findings, and results of our earlier investigations, demonstrate pronounced differences in AR sensitivity and pharmacokinetics among bird species, and in particular raptors. While ecological risk assessment and mitigation efforts for ARs have been extensive, AR exposure and adverse effects in predatory and scavenging wildlife continues. Toxicokinetic and toxicodynamic data will assist in such risk assessments and mitigation efforts. © 2023 The US Geological Survey
Authors & Co-Authors
Khidkhan, Kraisiri
Japan, Sapporo
Hokkaido University
Thailand, Bangkok
Kasetsart University
Saengtienchai, Aksorn
Japan, Sapporo
Hokkaido University
Thailand, Bangkok
Kasetsart University
Ogasawara, Kohei
Japan, Kushiro
Institute for Raptor Biomedicine Japan
Watanabe, Yukiko
Japan, Kushiro
Institute for Raptor Biomedicine Japan
Saito, Keisuke
Japan, Kushiro
Institute for Raptor Biomedicine Japan
Horikoshi, Kazuo
Unknown Affiliation
Suzuki, Hajime
Unknown Affiliation
Kawai, Yusuke K.
Japan, Obihiro
Obihiro University of Agriculture and Veterinary Medicine
Takeda, Kazuki
Japan, Tokyo
Kitasato University
Japan, Tokyo
Tokyo Institute of Technology
Yohannes, Yared Beyene
Japan, Sapporo
Hokkaido University
Ikenaka, Yoshinori
Japan, Sapporo
Hokkaido University
South Africa, Potchefstroom
North-west University
Ishizuka, Mayumi
Japan, Sapporo
Hokkaido University
Nakayama, Shouta M.
Japan, Sapporo
Hokkaido University
Zambia, Lusaka
University of Zambia
Statistics
Authors: 13
Affiliations: 11
Identifiers
Doi:
10.1016/j.envpol.2023.122837
ISSN:
02697491
Research Areas
Health System And Policy
Study Design
Cross Sectional Study
Study Approach
Quantitative