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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Influenza vaccine effectiveness in preventing influenza-associated hospitalizations during pregnancy: A multi-country retrospective test negative design study, 2010–2016
Clinical Infectious Diseases, Volume 68, No. 9, Year 2019
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Description
Background. To date, no study has examined influenza vaccine effectiveness (IVE) against laboratory-confirmed influenza-associated hospitalizations during pregnancy. Methods. The Pregnancy Influenza Vaccine Effectiveness Network (PREVENT) consisted of public health or healthcare systems with integrated laboratory, medical, and vaccination records in Australia, Canada (Alberta and Ontario), Israel, and the United States (California, Oregon, and Washington). Sites identified pregnant women aged 18 through 50 years whose pregnancies overlapped with local influenza seasons from 2010 through 2016. Administrative data were used to identify hospitalizations with acute respiratory or febrile illness (ARFI) and clinician-ordered real-time reverse transcription polymerase chain reaction (rRT-PCR) testing for influenza viruses. Overall IVE was estimated using the test-negative design and adjusting for site, season, season timing, and high-risk medical conditions. Results. Among 19 450 hospitalizations with an ARFI discharge diagnosis (across 25 site-specific study seasons), only 1030 (6%) of the pregnant women were tested for influenza viruses by rRT-PCR. Approximately half of these women had pneumonia or influenza discharge diagnoses (54%). Influenza A or B virus infections were detected in 598/1030 (58%) of the ARFI hospitalizations with influenza testing. Across sites and seasons, 13% of rRT-PCR-confirmed influenza-positive pregnant women were vaccinated compared with 22% of influenza-negative pregnant women; the adjusted overall IVE was 40% (95% confidence interval = 12%–59%) against influenza-associated hospitalization during pregnancy. Conclusion. Between 2010 and 2016, influenza vaccines offered moderate protection against laboratory-confirmed influenza-associated hospitalizations during pregnancy, which may further inform the benefits of maternal influenza vaccination programs. © The Author(s) 2018.
Authors & Co-Authors
Thompson, Mark G.
United States, Atlanta
Centers for Disease Control and Prevention
Kwong, Jeff C.
Canada, Toronto
Institute for Clinical Evaluative Sciences
Canada, Toronto
Public Health Ontario
Canada, Toronto
University of Toronto
Canada, Toronto
University Health Network University of Toronto
Regan, Annette K.
Australia, Perth
The Faculty of Health Sciences
Australia, Perth
Telethon Kids Institute
Katz, Mark A.
Israel, Tel Aviv-yafo
Clalit Health Services
Israel, Beer-sheva
Ben-gurion University of the Negev
United States, Ann Arbor
University of Michigan School of Public Health
Drews, Steven J.
Canada, Edmonton
University of Alberta
Azziz-Baumgartner, Eduardo
United States, Atlanta
Centers for Disease Control and Prevention
Klein, Nicola P.
United States, Oakland
Kaiser Permanente
Chung, Hannah
Canada, Toronto
Institute for Clinical Evaluative Sciences
Effler, Paul V.
Australia, Perth
Department of Health Western Australia
Dawood, Fatimah S.
United States, Atlanta
Centers for Disease Control and Prevention
Jackson, Michael L.
United States, Oakland
Kaiser Permanente
Fell, Deshayne Blayre
Canada, Toronto
Institute for Clinical Evaluative Sciences
Canada, Ottawa
University of Ottawa
Canada, Ottawa
Children's Hospital of Eastern Ontario, Ottawa
Levy, Avram
Australia, Perth
Queen Elizabeth Ii Medical Centre Trust
Fink, Rebecca V.
United States, Cambridge
Abt Associates, Inc.
Statistics
Citations: 119
Authors: 14
Affiliations: 19
Identifiers
Doi:
10.1093/cid/ciy737
ISSN:
10584838
Research Areas
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Participants Gender
Female