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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The effect of placental malaria infection on cord blood and maternal immunoregulatory responses at birth
European Journal of Immunology, Volume 40, No. 4, Year 2010
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Description
Placental malaria (PM), a frequent infection of pregnancy, provides an ideal opportunity to investigate the impact on immune development of exposure of the foetal immune system to foreign Ag.We investigated the effect of PM on the regulatory phenotype and function of cord blood cells from healthy Gambian newborns and peripheral blood cells from their mothers, and analyzed for effects on the balance between regulatory and effector responses. Using the gold standard for classifying PM we further distinguished between resolved infection and acute or chronic PM active at the time of delivery. We show that exposure to malarial Ag in utero results in the expansion of malaria-specific FOXP3 + Treg and more generalized FOXP3+ CD4+ Treg in chronic and resolved PM, alongside increased Th1 pro-inflammatory responses (IFN-γ, TNF-α, IFN-γ:IL-10) in resolved PM infection only. These observations demonstrate a clear effect of exposure to malarial Ag in foetal life on the immune environment at birth, with a regulatory response dominating in the newborns with ongoing chronic PM, while those with resolved infection produce both regulatory and inflammatory responses. The findings might explain some of the adverse effects on the health of babies born to women with PM. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
Authors & Co-Authors
Flanagan, Katie L.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Halliday, Alice
Gambia, Banjul
Medical Research Council Laboratories Gambia
Burl, Sarah
Gambia, Banjul
Medical Research Council Laboratories Gambia
Landgraf, Katja
Gambia, Banjul
Medical Research Council Laboratories Gambia
Jagne, Ya Jankey
Gambia, Banjul
Medical Research Council Laboratories Gambia
Noho-Konteh, F.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Townend, John A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Miles, David J.C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
South Africa, Cape Town
University of Cape Town
van der Sande, Marianne A.B.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Whittle, Hilton C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Rowland-Jones, Sarah Louise
Gambia, Banjul
Medical Research Council Laboratories Gambia
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
Statistics
Citations: 57
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1002/eji.200939638
e-ISSN:
15214141
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Participants Gender
Female