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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Association of serum 25-hydroxyvitamin D with lifestyle factors and metabolic and cardiovascular disease markers: Population-based cross-sectional study (FIN-D2D)
PLoS ONE, Volume 9, No. 7, Article e100235, Year 2014
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Description
Objectives: Low serum 25-hydroxyvitamin D (25OHD) level has been associated with an increased risk of several chronic diseases. Our aim was to determine lifestyle and clinical factors that are associated with 25OHD level and to investigate connection of 25OHD level with metabolic and cardiovascular disease markers. Design: In total, 2868 Finnish men and women aged 45-74 years participated in FIN-D2D population-based health survey in 2007. Participants that had a serum sample available (98.4%; n = 2822) were included in this study. 25OHD was measured with chemiluminescent microparticle immunoassay method. Results: The mean 25OHD level was 58.2 nmol/l in men (n = 1348) and 57.1 nmol/l in women (n = 1474). Mean 25OHD level was lower in the younger age groups than in the older ones (p<0.0001 both in men and women). This study confirmed that low physical activity (p<0.0001 both in men and women), smoking (p = 0.0002 in men and p = 0.03 in women) and high BMI (p<0.0001 in women) are factors that independently associate with low 25OHD level. Of the metabolic and cardiovascular disease markers high triglyceride concentration (p = 0.02 in men and p = 0.001 in women) and high apolipoprotein B/ apolipoprotein A1 ratio (p = 0.04 in men and p = 0.03 in women) were independently associated with low 25OHD level. Conclusions: Higher age did not predict lower 25OHD level in this study population of aged 45-74 years which may derive from a healthy life-style of "active pensioners". Low physical activity and smoking came up as independent lifestyle factors associated with low 25OHD level. Defining the molecular mechanisms behind the associations of 25OHD with low physical activity and smoking are important objective in future studies. The association of 25OHD with BMI, high triglyceride concentration and apolipoprotein B/apolipoprotein A1 ratio may be related to the role of vitamin D in inflammation, but more detailed studies are needed. © 2014 Miettinen et al.
Authors & Co-Authors
Miettinen, Maija E.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Kinnunen, L.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Leiviskä, Jaana
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Keinänen-Kiukaanniemi, Sirkka M.
Finland, Oulu
Oulun Yliopisto
Finland, Oulu
Oulu University Hospital
Korpi-Hyövälti, Eeva
Finland, Seinajoki
South Ostrobothnia Central Hospital
Niskanen, Leo K.
Finland, Helsinki
Finnish Medicines Agency
Finland, Kuopio
Itä-suomen Yliopisto
Oksa, Heikki H.
Finland, Tampere
University Hospital of Tampere
Saaristo, Timo E.
Finland, Tampere
Pirkanmaan Sairaanhoitopiiri
Finland, Tampere
Finnish Diabetes Association
Tuomilehto, Jaakko O.I.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Finland, Seinajoki
South Ostrobothnia Central Hospital
Austria, Krems an Der Donau
Donau-universität Krems
Saudi Arabia, Jeddah
King Abdulaziz University
Vanhala, M.
Finland, Kuopio
Itä-suomen Yliopisto
Finland, Jyvaskyla
Central Finland Central Hospital
Uusitupa, Matti
Finland, Kuopio
Itä-suomen Yliopisto
Finland, Kuopio
Kuopio University Hospital
Peltonen, Markku
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Statistics
Citations: 37
Authors: 12
Affiliations: 13
Identifiers
Doi:
10.1371/journal.pone.0100235
e-ISSN:
19326203
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Participants Gender
Male
Female